- Preparation method for clindamycin hydrochloride
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The invention specifically relates to a preparation method for clindamycin hydrochloride, belonging to the field of pharmaceutical chemistry. The preparation method comprises the following steps: (1) subjecting lincomycin hydrochloride and a Vilsmeier reagent to a chlorination reaction to obtain a chlorinated solution, wherein heating is gradually carried out in the process of the reaction; (2) cooling the chlorinated solution to 2 to 6 DEG C at a cooling rate of 14 to 20 DEG C/h, then carrying out a hydrolysis reaction in an aqueous solution of sodium hydroxide and then successively carrying out extraction, washing and concentration so as to obtain clindamycin free alkali; (3) subjecting the clindamycin free alkali and a saturated ethanol solution of hydrogen chloride to a salt formation reaction and carrying out crystallization, cooling, low-temperature crystallization and centrifugal washing so as to obtain a clindamycin hydrochloride alcohol adduct; and (4) subjecting the clindamycin hydrochloride alcohol adduct to dealcoholysis, crystallization, pumping filtration and drying so as to obtain clindamycin hydrochloride. Through optimization of the preparation method, yield is increased; impurity content is substantially reduced; and high-purity clindamycin hydrochloride is obtained.
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Paragraph 0018; 0019; 0020; 0021; 0022; 0023-0041
(2017/07/04)
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- A clindamycin phosphate ester synthesis method
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The invention belongs to the technical field of chemical synthesis and specifically relates to a synthetic method of clindamycin phosphate. The method comprises the following steps of synthesis of clindamycin free alkali, ketonization reaction, phosphorylation reaction and aftertreatment. According to the invention, the weight yield of the clindamycin phosphate can reach over 80% by changing a charging sequence, steps and a catalyst.
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Paragraph 0042-0043
(2017/02/28)
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- Composition and method for rectal delivery of a lincosamide antibiotic drug
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A suppository composition and method for rectal administration of a lincosamide antibacterial drug, such as clindamycin, lincomycin, or pirlimycin, is disclosed. The composition is a rectal suppository containing an antimicrobially effective amount of the lincosamide in particulate form dispersed in a Hard Fat suppository base, preferably a Hard Fat NF suppository base. The most preferred suppository compositions of the present invention have long term storage stability, while maintaining effectiveness against bacterial infections.
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- Method for treating inflammation
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A method of treating inflammation comprising topical administration to mammals suffering from an inflammatory condition not associated with amicrobial component, employing selected antibiotics as the anti-inflammatory agent.
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