Fluorinated and iodinated templates for syntheses of β-turn peptidomimetics
Various 2-fluoro-5-nitrobenzoic acids and the homocysteine derivative 2 have been combined in solid phase syntheses of the peptidomimetic types 3-6. NMR and CD data collected for some of these compounds indicate that a transannular SO to HN hydrogen bond stabilizes β-turn conformations for the sulfones and one of the sulfoxide epimers. An extensive library of compounds was made and studied to test this assertion.
Jiang, Luyong,Burgess, Kevin
p. 8743 - 8750
(2007/10/03)
Somatostatin receptor-binding peptides labeled with technetium-99m: Chemistry and initial biological studies
The synthesis of peptides which possess a high affinity for the somatostatin receptor and contain a chelator for the radionuclide technetium- 99m is described. The target compounds were designed such that they would form stable, oxotechnetium(V) chelate c
Pearson, Daniel A.,Lister-James, John,McBride, William J.,Wilson, David M.,Martel, Lawrence J.,Civitello, Edgar R.,Taylor, John E.,Moyer, Brian R.,Dean, Richard T.
p. 1361 - 1371
(2007/10/03)
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