- Reinvestigation of the synthesis of 1-deazauridine
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A thorough study for the synthesis of 1-deazauridine is described. 3-Bromo-2,6-dimethoxy-5-(-d-ribofuranosyl)pyridine, a synthetic precursor for 1-deazauridine, was prepared in seven steps from 2,6-dimethoxypyridine and d-ribose via the ribonolactone approach. Subsequent demethylation was unsuccessful but led to presumable anomerization and isomerization. The effort concluded that the synthesis of 1-deazauridine remained unachieved. Copyright Taylor and Francis Group, LLC.
- Jen, Cheng-Hung,Chien, Tun-Cheng
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- Organic semiconductor photocatalyst can bifunctionalize arenes and heteroarenes
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Photoexcited electron-hole pairs on a semiconductor surface can engage in redox reactions with two different substrates. Similar to conventional electrosynthesis, the primary redox intermediates afford only separate oxidized and reduced products or, more rarely, combine to one addition product. Here, we report that a stable organic semiconductor material, mesoporous graphitic carbon nitride (mpg-CN), can act as a visible-light photoredox catalyst to orchestrate oxidative and reductive interfacial electron transfers to two different substrates in a two- or three-component system for direct twofold carbon–hydrogen functionalization of arenes and heteroarenes. The mpg-CN catalyst tolerates reactive radicals and strong nucleophiles, is straightforwardly recoverable by simple centrifugation of reaction mixtures, and is reusable for at least four catalytic transformations with conserved activity.
- Ghosh, Indrajit,Khamrai, Jagadish,Savateev, Aleksandr,Shlapakov, Nikita,Antonietti, Markus,K?nig, Burkhard
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p. 360 - 366
(2019/08/15)
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- The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents
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A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the prese
- Lam, Kim Hung,Gambari, Roberto,Yuen, Marcus Chun Wah,Kan, Chi Wai,Chan, Penni,Xu, Lijin,Tang, Weijun,Chui, Chung Hin,Cheng, Gregory Yin Ming,Wong, Raymond Siu Ming,Lau, Fung Yi,Tong, Cindy Sze Wai,Chan, Andrew Kit Wah,Lai, Paul Bo San,Kok, Stanton Hon Lung,Cheng, Chor Hing,Chan, Albert Sun Chi,Tang, Johnny Cheuk On
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scheme or table
p. 2266 - 2269
(2009/12/25)
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- A CONVENIENT SYNTHESIS OF AZAANTHRAQUINONES VIA POLAR ADDITION TO HETARYNE INTERMEDIATES. USE OF CARBANIONS DERIVED FROM 32-CYANO-1(3H)-ISOBENZOFURANONES
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A convenient synthesis of 2-azaanthraquinones using the reaction of carbanions derived from 3-cyano-1(3H)-isobenzofuranones which serve as 1,4-dipole equivalents and hetaryne intermediates generated from bromopyridines and lithium diisopropylamide is reported.
- Khanapure, Subhash P.,Biehl, Edward R.
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p. 2643 - 2650
(2007/10/02)
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