- Synthesis and in vitro antitumor activity of 1,3,4-oxadiazole derivatives based on benzisoselenazolone
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A series of novel 1,3,4-oxadiazole derivatives based on benzisoselenazolone has been prepared and tested for antiproliferative activity in vitro against the cells of human cancer cell lines: SSMC-7721 (human liver cancer cell), MCF-7 (human breast cancer cell) and A549 (human lung cancer cell). All the compounds obtained exhibited antiproliferative activity and showed selective cytotoxicity against different cancer cells. Compounds 7d and 7i showed significant antiproliferative activities against MCF-7 cells, with IC50 values of 1.07 and 1.76/μM respectively. Compound 7d were found to be the most potent compound against SSMC-7721 cells, with IC50 values 4.46/μM.
- Luo, Zhen-Hua,He, Shuang-Yan,Chen, Bao-Quan,Shi, Yan-Ping,Liu, Yu-Ming,Li, Cai-Wen,Wang, Qiu-Sheng
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p. 887 - 891
(2012/08/14)
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- Green synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles at the platinum anode in acetic acid
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The electroorganic synthesis of 2-amino-5-substituted-1,3,4-oxadiazoles from the anodic oxidation of semicarbazone has been carried out at platinum anode in acetic acid under constant potential electrolysis in an undivided cell. This is an environmentally benign method in the field of synthetic organic chemistry. The products are characterized by IR, 1H and 13C NMR, and elemental analysis.
- Sharma, Laxmi Kant,Singh, Sushma,Singh
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p. 110 - 114
(2011/04/15)
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- Synthesis and Mass Spectral Studies of Some New 1,3,4-Oxadiazoles
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Some new 1,3,4-oxadiazoles have been synthesized in good yields from the reaction of aldehyde semicarbazones with bromine in presence of acetic acid and sodium acetate.The reaction proceeds through the formation of nitrilimine intermediate which on cycliz
- Bansal, R. K.,Bhagchandani, G.
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p. 277 - 279
(2007/10/02)
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