cas 168267-11-6, 2-METHOXY-5-(5-TRIFLUOROMETHYL-TETRAZOL-1-YL)-BENZALDEHYDE | Articles data ｜lookchem

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168267-11-6

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PHARMACEUTICAL COMPOSITIONS COMPRISING 2-METHOXY-5- (5-TRIFLUOROMETHYL-TETRAZOL-I-YL-BENZYL) - (2S-PHENYL-PIPERIDIN-3S-YL-)
The present invention relates to pharmaceutical compositions comprising the NK1 receptor antagonist [2-Methoxy-5-(5-trifuoromethyl-tetrazol-1-yl)-benzyl]-(2S-phenyl- piperidin-3S-yl)-amine, or a pharmaceutically acceptable salt or solvate thereof, and a sodium channel blocker, as a combined preparation for simultaneous or sequential administration and to the use of such compositions in the treatment of certain disorders, including epilepsy, mood disorders and pain.
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Page/Page column 19

(2008/12/07)

ALKOXYTETRAZOL-1-YLBENZALDEHYDE COMPOUND AND PROCESS FOR PRODUCING THE SAME
The present invention relates to a process for producing an alkoxy-(tetrazol-1-yl)benzaldehyde compound represented by Formula (2): wherein A1 is an alkoxy group, and A2 is a hydrogen atom, alkyl group or fluorine-substituted alkyl
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Page/Page column 10

(2008/06/13)

Synthesis of carbon-14 labelled NK-1 receptor antagonists GR203040 and GR205171
Syntheses of carbon-14 labelled versions of NK-1 receptor antagonists GR203040 and GR205171 are described. The carbon-14 atoms were introduced by palladium (0) catalysed cyanation of iodoaromatic substrates.
Cable, Karl M.,Wells, Guy N.,Sutherland, Derek R.
p. 29 - 45
(2007/10/03)

Tetrazole NK1 receptor antagonists: The identification of an exceptionally potent orally active antiemetic compound
The medicinal chemistry strategy which led to the identification of GR205171, an orally active non-peptide neurokinin-1 receptor antagonist that is the most potent broad-spectrum antiemetic agent reported to date.
Armour,Chung,Congreve,Evans,Guntrip,Hubbard,Kay,Middlemiss,Mordaunt,Pegg,Vinader,Ward,Watson
p. 1015 - 1020
(2007/10/03)

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Chemical Properties

Boiling Point: 374.9±52.0 °C(Predicted)
Density: 1.52±0.1 g/cm3(Predicted)
PKA: -0.43±0.10(Predicted)
PSA: 69.90000
LogP: 1.50220

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