- A molecular box derived from cobaloxime units held together by 4-pyridinylboronic acid residues
-
The reaction of CH3Co(DH)2H2O with 4-pyridinyl boronic acid in methanol or water affords the dinuclear complexes [MeCo(DH)(DB(OR)(4-Py))]2, with R = Me (2) or H (3), respectively, through reaction of boron with the oxime oxygens of the alkylcobaloxime and coordination of the pyridinyl N to cobalt. The reaction is strongly pH dependent, and the formation of the complexes requires a neutral medium. The complexes have been fully characterized by 1H and 13C NMR spectroscopy, ESI-MS spectrometry, and elemental analysis. The X-ray structure shows that in 2, the pyridinyl groups are facing each other and nearly perpendicular both to the plane of the Co B Co1 B 1 atoms and to the mean equatorial plane, so that the complex may be considered a molecular box. A dimeric arrangement has already been found in the related [MeCo(DH)(DB(OMe)(3-Py))]2 (1) complex, which forms a distorted molecular rectangle [Dreos, R.; Nardin, G.; Randaccio, L.; Tauzher, G.; Vuano, S. Inorg. Chem. 1997, 36, 2463]. The dimerization is possible in both cases, as the conformational freedom of the B bridge compensates for the different position (3- or 4-) of the pyridinyl N donor.
- Dreos,Nardin,Randaccio,Siega,Tauzher,Vrdoljak
-
-
Read Online
- Organocatalytic diboration involving "reductive addition" of a boron-boron-bond to 4,4′-bipyridine
-
A 4,4′-bipyridine-based catalyst system for diboration of pyrazine derivatives was established. The catalyst cycle consists of the following two steps: (1) reductive addition of the boron-boron bond of bis(pinacolato)diboron to 4,4′-bipyridine to form N,N
- Ohmura, Toshimichi,Morimasa, Yohei,Suginome, Michinori
-
-
Read Online
- Nitrogen-containing compound, electronic element and electronic device
-
The invention provides a nitrogen-containing compound, an electronic component and an electronic device, and relates to the technical field of organic materials, wherein the nitrogen-containing compound is represented by a formula I, X is selected from oxygen and sulfur, R is selected from heterocycloalkyl and heteroaryl, L is selected from a single bond, arylene and heteroarylene, the substituentof R is selected from deuterium, nitro, hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, alkoxy, aryl silyl and alkyl silyl, and the substituent of L is selected from deuterium, nitro, hydroxyl, alkyl, cycloalkyl, alkenyl, alkynyl, heterocycloalkyl, alkoxy, alkylsilyl, arylsilyl, aryloxy and arylthio. The nitrogen-containing compound disclosed by the invention can reduce the working voltage of an electronic component, improve the efficiency of a device and prolong the service life of the device.
- -
-
Paragraph 0143-0145
(2020/05/01)
-
- Synthetic process for pyridine-4-boronic acid
-
The invention discloses a synthetic process for pyridine-4-boronic acid. The synthetic process comprises the following steps: with 4-bromopyridine hydrochloride as a raw material, carrying out dissociation under an alkaline condition so as to obtain 4-bromopyridine; adding alkyl magnesiumlithium and a haloboron reagent at a low temperature, and carrying out distillation so as to obtain a pyridine-4-boron amine intermediate; and carrying out exchanging and hydrolysis so as to obtain pyridine-4-boronic acid. The method overcomes the problem that free 4-bromopyridine is prone to polymerization, avoids the influence of the characteristic that pyridine-4-boronic acid has zwitterions, and realizes maximum product precipitation. The process has been verified on a scale of kilograms.
- -
-
Paragraph 0017-0028
(2018/04/21)
-
- Synthesis of Pyridylanthracenes and Their Reversible Reaction with Singlet Oxygen to Endoperoxides
-
The ortho, meta, and para isomers of 9,10-dipyridylanthracene 1 have been synthesized and converted into their endoperoxides 1-O2 upon oxidation with singlet oxygen. The kinetics of this reaction can be controlled by the substitution pattern an
- Fudickar, Werner,Linker, Torsten
-
p. 9258 - 9262
(2017/09/11)
-
- Based on 4,4 the structure of the- [...][...] 9, the 9-bit [...] a main body material and its application (by machine translation)
-
Based on 4,4 the structure of the- [...][...] 9, the 9-bit [...] a main body material and its application, the present invention discloses a kind HOMO line condition and at the same time has a high level and the main material with excellent performance, its to 4, the 4-bit connected [...][...] as the molecule skeleton structure, in its 9,9 the connecting substituent [...] -position, which can be connected with transmission performance of the cavity diphenylammonium unit Dn, but also can be connected with electronic transmission performance unit An: phosphorusoxychloride unit, sulfur and oxygen unit, in addition to the two special spiral ring-like structure can be formed. The main body material of the present invention synthetic method is simple and easy to operate, which is suitable to be widely used. Main body material by the present invention of the organic electroluminescent light-emitting device is phosphorescent blue light, has high efficiency, high brightness, low efficiency low starting voltage attenuation and electroluminescent performance, can be widely applied to the organic electroluminescent field. (by machine translation)
- -
-
Paragraph 0064; 0065
(2016/10/10)
-
- COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF
-
The present invention provides a novel compound capable of improving light emitting efficiency, stability and lifespan of an element, an organic electronic element using the same and an electronic device thereof.(110) Substrate(120) Positive electrode(130) Hole injection layer(140) Hole transfer layer(141) Buffer layer(150) Light emitting layer(151) Light-emitting assisting layer(160) Electron transfer layer(170) Electron injection layer(180) Negative electrodeCOPYRIGHT KIPO 2016
- -
-
Paragraph 0157; 0166; 0167
(2016/10/07)
-
- Structure-based design, synthesis and biological evaluation of diphenylmethylamine derivatives as novel Akt1 inhibitors
-
A series of diphenylmethylamine derivatives were rationally designed, synthesized and biologically evaluated. Most of them exhibited moderate to good Akt1 inhibitory activities, as well as promising anti-proliferative efficacy against cancer cell lines. Besides, molecular docking studies were carried out to probe their binding modes with Akt1. Further kinase selectivity studies of compound 22c were performed, indicating its excellent selectivity against Aurora A, Drak, IKKβ, GSK3β, SYK and JAK2, and moderate selectivity against PKC and BRAF. Finally, a refined pharmacophore model was generated using the most active compounds 2, 12c and 22c via application of HipHop program.
- Liu, Tao,Zhan, Wenhu,Wang, Yanming,Zhang, Liangren,Yang, Bo,Dong, Xiaowu,Hu, Yongzhou
-
p. 167 - 176
(2014/01/17)
-
- Further delineation of hydrophobic binding sites in dopamine D 2/D3 receptors for N-4 substituents on the piperazine ring of the hybrid template 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5, 6,7,8-tetrahydro-naphthalen-2-ol
-
Here we report a structure-activity relationship (SAR) study of analogues of 5/7-{[2-(4-aryl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol. Our SAR is focused on introduction of various substitutions in the piperazine ring of the hybrid template. The goal behind this study is to delineate the nature of the binding pocket for N-aryl substitution in the piperazine ring by observing the effect of various hydrophobic and other heteroaromatic substitutions on binding affinity (Ki), as measured with tritiated spiperone and HEK-293 cells expressing either D2 or D3 receptors. Functional activity of selected compounds was assessed with the GTPγS binding assay. Compound 8d was the most selective for the D3 receptor in the spiperone binding assay. An interesting similarity in binding affinity was observed between isoquinoline derivative D-301 and the 2-substituted pyridine derivative 8d, suggesting the importance of relative spatial relationships between the N-atom of the ligand and the molecular determinants of the binding pocket in D2/D3 receptors. Functional activity assays demonstrated high potency and selectivity of (+)-8a and (-)-28b (D2/D3 (ratio of EC50): 105 and 202, respectively) for the D3 receptor and both compounds were more selective compared to the reference drug ropinirole (D2/D3 (ratio of EC50): 29.5).
- Ghosh, Balaram,Antonio, Tamara,Gopishetty, Bhaskar,Reith, Maarten,Dutta, Aloke
-
experimental part
p. 5661 - 5674
(2010/10/01)
-
- An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids
-
3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench". This technique was further studied and evaluated on other aryl halides in the preparation of arylboronic acids.
- Li, Wenjie,Nelson, Dorian P.,Jensen, Mark S.,Hoerrner, R. Scott,Cai, Dongwei,Larsen, Robert D.,Reider, Paul J.
-
p. 5394 - 5397
(2007/10/03)
-
- Substituted pyridine and pyridazine compounds and methods of use
-
Selected novel substituted pyridine and pyridazine compounds are effective for prophylaxis and treatment of diseases, such as TNF-α, IL-1β, IL-6 and/or IL-8 mediated diseases, and other maladies, such as cancer, pain and diabetes. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving inflammation, cancer, pain, diabetes and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
- -
-
-