cas 169447-76-1, (S)-1-N-Boc-2-butylpiperazine | Articles data ｜lookchem

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169447-76-1

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17 Beta-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
In its many embodiments, the present invention provides a novel class of compounds as inhibitors of type 3 17β-hydroxysteroid dehydrogenase, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of
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Page 20

(2008/06/13)

INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras
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(2008/06/13)

Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. The compounds of formula A are representative of the compounds of the present invention: STR1
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(2008/06/13)

2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase [1]
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Williams,Ciccarone,MacTough,Bock,Conner,Davide,Hamilton,Koblan,Kohl,Kral,Mosser,Omer,Pompliano,Rands,Schaber,Shah,Wilson,Gibbs,Graham,et al.
p. 1345 - 1348
(2007/10/03)

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Chemical Properties

Boiling Point: 320.53 °C at 760 mmHg
Flash Point:147.652 °C
Density: 0.964 g/cm³
Storage Temp.:2-8°C(protect from light)
Vapor Pressure: 0.000316mmHg at 25°C
Refractive Index: 1.459
PKA: 8.49±0.40(Predicted)
PSA: 41.57000
LogP: 2.65220

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