cas 169448-17-3, (S)-tert-butyl 2-(2-hydroxyethyl)piperazine-1-carboxylate | Articles data ｜lookchem

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169448-17-3

Articles about 169448-17-3Total 5 be found

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CYCLIC (AZA)INDOLIZINECARBOXAMIDES, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
The present invention relates to cyclic indolizinecarboxamides and azaindolizinecarboxamides of the formulae Ia and Ib, (Ia) (Ib) wherein R, Ra, R10, R20, R30, R40, Y, n, p and q have the meanings ind
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(2011/02/24)

Prenyl transferase inhibitors
A family of compounds capable of inhibiting the activity of prenyl transferases. The compounds are covered by the four following formulas Each of the R groups is defined in the disclosure.
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(2008/06/13)

Thioproline-containing inhibitors of farnesyl protein transferase
Inhibition of farnesyl transferase, which is an enzyme involved in ras oncogene expression, is effected b STR1 its enantiomers, diastereomers, and pharmaceutically acceptable salts and solvates thereof.
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(2008/06/13)

Inhibitors of farnesyl-protein transferase
The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras. The compounds of formula A are representative of the compounds of the present invention: STR1
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(2008/06/13)

2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase [1]
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Williams,Ciccarone,MacTough,Bock,Conner,Davide,Hamilton,Koblan,Kohl,Kral,Mosser,Omer,Pompliano,Rands,Schaber,Shah,Wilson,Gibbs,Graham,et al.
p. 1345 - 1348
(2007/10/03)

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Chemical Properties

Boiling Point: 339.1oC at 760 mmHg
Flash Point:158.9oC
Density: 1.067g/cm3
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 6.34E-06mmHg at 25°C
PKA: 15.11±0.10(Predicted)
PSA: 61.80000
LogP: 0.84440

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