SULFOXONIUM YLIDE DERIVATIVES AS PROBES FOR CYSTEINE PROTEASE
The present invention relates to compounds of formula I bearing a sulfoxonium ylide moiety as warhead, or salts thereof. Such compounds can be used as activity-based probes for cysteine proteases such as cathepsin X, in methods of detecting cysteine protease activity and in related diagnostic or therapeutic methods.
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Paragraph 0367; 0374-0376
(2020/07/14)
Oxo-ester mediated native chemical ligation: Concept and applications
A direct oxo-ester peptide ligation method has been developed. Through the use of an activated C-terminal para nitrophenyl ester (1), it is possible to achieve direct cysteine ligations (1 + 2 → 4). Peptide substrates incorporating bulky C-terminal amino acids (1) can be accommodated with high reaction efficiency. Copyright
Wan, Qian,Chen, Jin,Yuan, Yu,Danishefskr, Samuel J.
supporting information; scheme or table
p. 15814 - 15816
(2009/05/16)
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