The second generation synthesis of (±)-berkeleyamide D
Previously, our group reported the first synthesis of (±)-berkeleyamide D, optical resolution of both enantiomers, and determination of their absolute configuration. The synthesis provided (±)-berkeleyamide D in a total of eight steps from commercially av
The present invention provides AKT inhibitors of the formula: Formula I The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and method of using compounds of Formula I.
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Structure-activity Relationship of Herbicidal 2,3-Dicyano-5-Substituted Pyrazines
Sixty six 2,3-dicyano-5-substituted pyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests to clarify the relationship between chemical structure and activity.The activity of 59 derivatives was related parabolically to the hydrophobic substituent parameter at the 5-position of the pyrazine ring.