SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS
Provided are pyridopyrazine compounds of formula (1), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, R4 and m are as defined in the specification.
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Paragraph 0366; 0367
(2014/05/08)
Synthesis and biological activities of metabolites of mosapride, a new gastroprokinetic agent
In order to confirm the proposed structures of two metabolites 3 and 4 of the gastroprokinetic agent mosapride [4-amino-5-chloro-2-ethoxy-N-{[4-(4-fluorobenzyl)-2 -morpholinyl]methyl}benzamide, 2], the compounds were synthesized and their biological activity was examined. The structures of the metabolites were confirmed by means of comparison with the synthetic compounds. The serotonin 5-HT4 receptor agonistic activities of the metabolites were found to be less than that of mosapride.
Kato,Morie,Yoshida
p. 699 - 702
(2007/10/02)
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