Synthesis and reactivity of 5-fluorouracil/cytarabine mutual prodrugs
Two mutual prodrugs, in which two different anti-cancer drugs are attached to the same molecule via labile linkages, are synthesized and examined kinetically. One of the mutual prodrugs loses a drug component under physiological conditions within an hour, but the other mutual prodrug (having a longer spacer between the two drugs) is stable to chemical degradation even at hither pH values. Thus, enzymatic hydrolysis alone will release the two anti-cancer drugs. The potential value of anti-cancer mutual prodrugs is discussed.
Menger, Fredric M.,Rourk, Michael J.
p. 9083 - 9088
(2007/10/03)
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