- α-Oxothiones, IV: Electrophilic substitution of phenols with α,α′-dioxothiones and ortho-thioquinones
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α,α′-Dioxothione 1a and ortho-thioquinones 2a and 2b are able to react with several phenols and N,N-dimethylaniline to give the corresponding alkyl aryl or diaryl sulfides. The mechanism of this reaction was proved to be an electrophilic aromatic substitu
- Capozzi, Giuseppe,Menichetti, Stefano,Nativi, Cristina
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- Efficient route for the synthesis of new dinaphthosulfoxide aza crowns using ethyleneglycol under microwave (mw) irradiation: Macrocyclization is preferred to oligomerization under MW irradiation
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New dinaphthosulfoxide aza crowns were prepared from the corresponding dinaphthosulfoxide diester and diamines under reflux conditions (conventional heating) and microwave (MW) irradiation. These reaction routes were used for the synthesis of a series of aza crowns, such as dinaphthosulfide, dinaphthosulfone, dibenzosulfide, and dibenzosulfoxide. The synthesis of aza crowns under MW irradiation in comparison with conventional heating has several advantages, such as shorter reaction times, simpler reaction conditions, and the use of ecofriendly solvents, higher yields, and regioselectivity. In the MW synthesis, macrocyclization is preferred to oligomerization, and thus, the yields of byproducts are low. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Taylor & Francis Group, LLC.
- Rostami, Esmael
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- BINOL aza macrocycle derivatives: Synthesis of dinaphthosulfone aza macrocycles using p-toluenesulfonic acid (p-TsOH) in methanol as an efficient route and evaluation of their 1H NMR spectra
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Dinaphthosulfone aza macrocycles were synthesized from the reaction of diamines and dinaphthosulfone diester (1,1'-sulfoxobis-(2-naphthoxy(2-methyl acetate))) in methanol in the presence of catalytic amounts of para toluenesulfonic acid (p-TsOH). Dinaphthosulfone diester (1,1'-sulfoxobis-(2- naphthoxy(2-methyl acetate))) was synthesized from the corresponding dinaphthosulfide diester and hydrogen peroxide in formic acid at room temperature. Dinaphthosulfide diester was prepared from initial dinaphtholsulfide diol (1,1'-thio bis(2-hydroxy naphthalene)) and methylchloroacetate. 1H NMR spectroscopy showed the unusual splittings for these dinaphthosulfone aza macrocycles, and this finding could be proposed as the role of tetrahedral structure of sulfone functional group, hydrogen bonding in the cavity and size of macrocycle.
- Rostami, Esmael,Shockravi, Abbas,Fattahi, Hanif,Heydarian, Davood,Minaee, Shima Shahbanzadeh,Naghdi, Shaghayegh,Lotf, Ebrahim Abouzari,Sadeghpour, Mahdieh,Hosseini, Hamideh,Taheri, Zahra,Ghorbani, Shahla,Javadi, Ali,Ataei, Shahram Mehdipoure
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- A simple and efficient synthesis and dynamic NMR studies of some new podands of dithiocarbamates formed from bis(naphthyl) derivatives
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The reaction of dithiocarbamate salts (IVa - c) with bis(naphthalene chloroacetates) (IIa,b) and bis(naphthalene ethoxybromide) (IIc) in dimethylformamide (DMF) furnished corresponding podands as Va - i in high to excellent yields. Three reacting ligands, (IIa,b) and (IIc), were obtained in the reaction of bis(naphthalene) (Ia,b) with chloroacetylchloride and 1,2-dibromoethane. Dynamic NMR spectroscopic data of three series of podands (Va - c, Vd-f, and Vg - i) are discussed, and their free energy of activation (Δ GC≠) at coalescence temperatures are figured out. The Δ GC ≠ s of these podands were attributed to conformational isomerization in the range of 14.5-18.3 kcal mol-1 due to rotation and resonance effects about thioamide C-N bond. Copyright
- Shockravi, Abbas,Kamali, Mahmood,Sorkhei, Farhad,Jafari, Reza
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- ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF
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Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.
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Page/Page column 22; 24; 26; 27
(2021/06/22)
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- Polymercaptan compound for optical resin material and preparation method thereof
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The invention discloses a polymercaptan compound for an optical resin material and a preparation method thereof. The index of refraction of the polymercaptan compound is increased in the manner of introducing sulfur-containing electron-rich conjugate constitutional unit-sulfo-binaphthyl with high mole refrangibility and thioether bonds into the polymercaptan compound. The index of refraction of the polymercaptan compound is effectively increased.
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Paragraph 0023; 0025; 0029; 0031; 0035; 0037; 0041; 0043
(2019/01/14)
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- Benzimidazole conjugate of 1,1′-thiobis(2-naphthol) as switch-on fluorescence receptor for Ag+ and the complex as secondary recognition ensemble toward Cys, Asp, and Glu in aqueous methanolic solution: Synthesis, characterization, ion and amino acid recognition, computational studies, and microscopy features
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A new 1,1′-thiobis(2-naphthoxy)-based receptor molecule (L) containing a benzimidazole moiety has been synthesized and characterized by 1H NMR, ESI-MS, and elemental analysis. The selectivity of L has been explored in aqueous methanol, resulting in selective (7.5 ± 0.5)-fold switch-on fluorescence response toward Ag+ among 14 different transition, alkali, and alkaline earth metal ions studied. The complexation of Ag+ by L has been addressed by ESI-MS, 1H NMR, and UV-vis spectra. Microstructural features of L and its Ag+ complex have been measured by AFM and TEM. The morphological features of L alone and L in the presence of Ag+ differ dramatically both in shape and size, and the ion induces the formation of chains owing to its coordinating ability toward benzimidazole. Further, the in situ [Ag+-L] complex was titrated against 20 naturally occurring amino acids and found that this complex acts as a secondary recognition ensemble toward Cys, Asp, and Glu by switch-off fluorescence.
- Dessingou, Jayaraman,Mitra, Atanu,Tabbasum, Khatija,Baghel, Garima Singh,Rao, Chebrolu P.
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experimental part
p. 371 - 378
(2012/02/15)
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- Efficient routes for the synthesis of dinaphthosulfide (BINOL Derivatives) and dibenzosulfide aza podands containing ethanolamine
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Four new dinaphthosulfide and dibenzosulfide aza podands were synthesized. The synthesis of these podands was performed under three different reaction conditions: 1) diester, K2CO3, methanol, and RT; 2) diester, ethanolamine, and microwave (MW); and 3) diacid dichloride, ethanolamine, Et3N, CH2Cl2, RT. Two kinds of diester (dinaphthosulfide and dibenzosulfide) were used for the preparation of dihydroxy podands. These dihydroxy podands were reacted with thionyl chloride to afford dichloro podands. The second route gave excellent yields of dihydroxy podands. Dichloro podands are more soluble than dihydroxy podands in conventional solvents such as methanol, chloroform, and acetonitrile.
- Rostami, Esmael,Heidaryan, Davood,Fattahi, Hanif,Shockravi, Abbas,Zarei, Mehdi,Rakhshanderu, Farokh
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body text
p. 1924 - 1934
(2010/02/28)
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- Modified BINOL podands: Synthesis of dinaphthosulfide podands and their application in spectrophotometric determination of toxic metals
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New dinaphthosulfide podands [3(a, b, and c)] were synthesized. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR, and Mass spectra. A simple, efficient, and sensitive procedure is described for the spectrophotometric determination of a trace amount of Ag+, Hg2+, Cr3+, Pb2+, and Ni2+ cations in the presence of Mn2+, Co2+, Cd2+ cations using the podand (3a). Formation constants of 1:1 complexes were determined from the absorbance-mole ratio data and found to vary in the order Pb2+ Ni2+ Hg2+ Cr3+ Ag+.
- Shockravi, Abbas,Chaloosi, Marzieh,Rostami, Esmael,Heidaryan, Davood,Shirzadmehr, Ali,Fattahi, Hanif,Khoshsafar, Hamid
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p. 2115 - 2123
(2008/02/08)
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- Utilisations synthetiques d'une electrode soluble au soufre. III. Creation de l'enchainement C-S-C a partir d'ethers aromatiques et de phenols
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Use of a sacrificial sulfur electrode in electroorganic chemistry.III.Formation of the C-S-C bond from aromatic ethers and phenols.At a working potential of about +2.2 V (vs SCE) the carbon-sulfur electrode is a source of the electrogenerated cation S2+ in organic media.This electrophile can react with aromatic ethers and phenols to produce the corresponding monosulfides.This reaction may be regioselective. carbon-sulfur electrode / sacrificial electrode /sulfur cation / organic sulfide / electrophilic substitution
- Elothmani, Driss,Do, Quang Tho,Simonet, Jacques,Guillanton, Georges Le
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p. 779 - 788
(2007/10/02)
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