- A phenoxy quinoline and its synthetic method (by machine translation)
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The invention discloses a phenoxy quinoline and its synthetic method, the phenoxy quinoline comprises the following raw materials: water, ethyl acrylate, zinc chloride, glacial acetic acid, 3, 5 - dichloroaniline, ethanol, sodium hydroxide, toluene, poly phosphoric acid, n-octane, Pd/C catalyst, dichloroethane, phosphorus oxychloride, para-phenol and N, N - dimethyl formamide. This invention resulting of phenoxy quinoline content of greater than 98.0%, yield is 50% or more, the production cost is low, its synthetic combinations not needed in the process by the hydrolysis, such as high-temperature decarboxylation process, less operation step, mild reaction conditions, low equipment requirements, production of good product quality, is suitable for large-scale production enterprises. (by machine translation)
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- Oxidation method of 4-oxo-2,3-dihydroquinoline compound
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The invention discloses an oxidation method of a 4-oxo-2,3-dihydroquinoline compound. The method comprises the following steps: taking the 4-oxo-2,3-dihydroquinoline compound as a raw material; addingan organic solvent, an acidifying agent and an oxidizing agent; performing oxidation reaction at 50-85 DEG C; and after the reaction is finished, performing post-treatment on the reaction liquid to obtain a 4-hydroxyquinoline compound. Various raw materials used by the preparation method disclosed by the invention are simple and easy to obtain, are industrial products and have wide sources and low price; the preparation method is simple, easy to operate and high in product yield; compared with the traditional oxidation method of the 4-oxo-2,3-dihydroquinoline compound, the method disclosed bythe invention has the advantages of being more efficient and simpler in post-treatment; and the method is especially important for the industrialization of the product.
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Paragraph 0016
(2018/12/05)
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- Method for preparing 4-hydroquinolines and/or tautomeric compounds
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The invention concerns a method for preparing 4-hydroquinolines and/or tautomeric compounds. More particularly, the invention concerns 5,7-dichloro-4-quinolines and/or its tautomeric compounds. The method is characterized in that it consists in heating a 4-hydroquinolinecarboxylic acid, its derivatives or precursors, at a temperature not more than 200° C. in the presence of a base.
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Page column 7-8
(2008/06/13)
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- Development of an efficient process for 4,5,7-trichloroquinoline, a key intermediate for agrochemical synthesis
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A short, simple, and industrially feasible process for the preparation of 4,5,7-trichloroquinoline, starting from 3,5-dichloroaniline and acrylonitrile, in essentially three steps, is discussed. This article presents the preparative process, including the
- Chandrasekhar,Prasad,Eswaraiah,Venkateswaralu
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p. 242 - 245
(2013/09/06)
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- Catalytic enantioselective reissert-type reaction: Development and application to the synthesis of a potent NMDA receptor antagonist (-)-L-689,560 using a solid-supported catalyst
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Full details of the first catalytic enantioselective Reissert-type reaction are described. Utilizing the Lewis acid-Lewis base bifunctional catalyst 5 or 6 (9 mol %), the Reissert products were obtained in 57 to 99% yield with 54 to 96% ee. Electron-rich
- Takamura,Funabashi,Kanai,Shibasaki
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p. 6801 - 6808
(2007/10/03)
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- Intermediates for producing 5,7-dichloro-4-hydroxyquinoline
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An industrially advantageous process for producing 5,7-dichloro-4-hydroxyquinoline (DCHQ) useful as an intermediate for agrohorticultural bactericides. The process comprises (i) hydrolyzing 3-cyano- or 3-ethoxycarbonyl-5,7-dichloro-4-hydroxyquinoline into 5,7-dichloro-3-carboxy-4-hydroxyquinoline (DCQA) in the presence of hydrochloric, sulfuric or phosphoric acid and (ii) decarboxylating the formed DCQA into DCHQ in the presence of sulfuric or phosphoric acid. In particular, this process comprises continuously conducting the hydrolysis of 5,7-dichloro-3-ethoxycarbonyl-4-hydroxyquinoline and the decarboxylation of the hydrolyzate in the presence of sulfuric acid having a specified concentration. The invention also relates to a process for producing DCQA by hydrolyzing 3-cyano- or 3-ethoxycarbonyl-5,7-dichloro-4-hydroxyquinoline in the presence of hydrochloric, sulfuric or phosphoric acid and a process for producing DCHQ by decarboxylating DCQA in the presence of sulfuric or phosphoric acid.
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