Solid Phase Synthesis of C-Terminal Peptide Aldehydes
Peptides with C-terminal aldehydes (PAs) are of interest due to their inhibitory properties toward numerous classes of proteolytic enzymes. In this paper, we describe and compare two novel approaches for the preparation of PAs by solid phase synthesis, on
Improved solid phase synthesis of C-terminal peptide aldehydes
A new linker based on the Weinreb amide was developed in order to synthesize from peptidyl-resin the corresponding aldehydic peptides by reduction with LiAlH4.This new reaction was tested with N-protected amino-residues and with tripeptides to obtain the