Synthesis and antitubercular activity of substituted phenylmethyl- and pyridylmethyl amines
A total of 42 benzyl- and pyridylmethyl amines were synthesized either by reductive amination of aromatic/heteroaromatic aldehydes with amines or by conjugate addition of amines to the cinnamates followed by reduction of the ester group with lithium aluminium hydride to the respective propanolamines. All the synthesized compounds were evaluated against both avirulent and virulent strains of Mycobacterium tuberculosis. Many of the compounds exhibited MIC as low as 1.56 μg/mL. Few of potent compounds were also evaluated against clinical isolates of MDR TB and found to be active at one or other concentrations with MIC as low as 3.12 μg/mL.
Selective Functionalisation. Part 11. Selective Hydrogenation by a Novel Palladium Salicylidene-ethylenediamine Complex and the Properties of Derivatives of some Square Planar Homogenous Hydrogenation Catalysts.
Analogues of two reported homogenous hydrogenation catalysts based upon square planar palladium complexes have been prepared with a view to modifying the structures to permit the control of selectivity by micellar interactions.Derivatives of bisacetylacetonatopalladium(II) in which the diketone was alkylated at C-3 or C-5 were prepared but no useful catalytic activity was observed for the reduction of nitrobenzene to aniline in the presence of pyridine.Complexes were also prepared from bisacetylacetonatopalladium(II) with 4-substituted pyridines as ligands; 4-tridecylpyridine afforded an unstable complex but 4-decylaminopyridine afforded a stable complex with low catalytic activity.A series of salicylidene imine palladium(II) complexes was prepared.Contrary to previous reports, the well-known salicylidene-ethylenediaminepalladium(II) complex was not a catalyst for homogenous hydrogenation but a new oligomeric green heterogenous complex with selective hydrogenation properties was discovered.This green complex was selective for the hydrogenation of alkynes, especially terminal alkynes, and reduced few other functional groups (ArNO2, ArCHO).Many variations on this structure were investigated in an attempt to discover a soluble or crystalline analogue of the green complex but no complexes with improved properties were isolated.
Kerr, James M.,Suckling, Colin J.,Bamfield, Peter
p. 887 - 895
(2007/10/02)
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