- Enantioselective Phenol Coupling by Laccases in the Biosynthesis of Fungal Dimeric Naphthopyrones
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Biaryl compounds are ubiquitous metabolites that are often formed by dimerization through oxidative phenol coupling. Hindered rotation around the biaryl bond can cause axial chirality. In nature, dimerizations are catalyzed by oxidative enzymes such as la
- Obermaier, Sebastian,Thiele, Wiebke,Fürtges, Leon,Müller, Michael
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supporting information
p. 9125 - 9128
(2019/06/13)
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- Biomimetic Synthesis of Polyketide Aromatics from Reaction of an Orsellinate Anion with Pyrones and a Pyrylium Salt
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Orsellinate anion (12) shows highly regioselective attack on pyrones (13), (22), and (30), and the products were simply converted into derivatives of the polyketides: toralacton (19), 6-hydroxymusizin (26), and eleutherinol (32); although reaction of the anion (12) with the pyrylium salt (33) is less selective, the minor product (34) can give derivatives of either alternariol (36) or rubrofusarin (37) in regiospecific biomimetic reactions.
- Leeper, Finian J.,Staunton, James
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p. 1053 - 1059
(2007/10/02)
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