- A new synthetic route towards aliskiren intermediates
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The synthesis of aliskiren intermediates was accomplished by attaching the 3,4-dialkoxyphenyl unit to precursor C-8 lactone-carboxylic acid derivatives using organometallic reagents. Totally different reactivities of the lactone-carboxylic acid chloride substrate towards organomagnesium and organoboron reagents were observed.
- Pogan, Franc,tefane, Bogdan,Kidemet, Davor,Smodi, Janez,Zupet, Rok
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p. 3221 - 3228
(2015/01/08)
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- METHODS OF TREATING ALZHEIMER’S DISEASE USING AROMATICALLY SUBSTITUTED ω-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES
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Disclosed.are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein the variables R1, R2, R3, R4, R5, X1, and X2 are defined herein.
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Page 159; 160
(2010/02/05)
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