- Compound as potassium channel modulator
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The invention relates to a compound as a potassium channel modulator, which is a compound of a formula (I) or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof is effective for curing and preventing diseases and symptoms influenced by the activity of potassium ion channels.
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Paragraph 0606; 0608; 0609; 0610
(2018/07/30)
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- HETEROCYCLIC COMPOUNDS AS AXL INHIBITORS
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Compounds of Formula I and their uses of effective AXL inhibitors and for the treatment of physical condition mediated by AXL.
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Paragraph 052; 059
(2016/01/15)
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- Synthesis of 3-substituted tetrahydrofuran and 4-substituted tetrahydropyran derivatives by cyclization of dicarboxylic acids with InBr 3/TMDS
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An efficient reduction followed by cyclization of diacid compounds with the InBr3/TMDS system is reported. This system allows the formation of five- and six-membered ring ethers substituted in the 3- or 4-position. Copyright
- Pehlivan, Leyla,Metay, Estelle,Delbrayelle, Dominique,Mignani, Gerard,Lemaire, Marc
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supporting information; experimental part
p. 4689 - 4693
(2012/09/22)
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- FUSED BICYCLIC DERIVATIVES OF 2,4-DIAMINOPYRIMIDINE AS ALK AND C-MET INHIBITORS
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The present invention provides a compound of formula I or II or a pharmaceutically acceptable salt form thereof, wherein R1, R2, R3, R4, R5, A1, A2, A3, A4, and A5, are as defined herein. The compounds of formula I or II have ALK and/or c-Met inhibitory activity, and may be used to treat proliferative disorders.
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Page/Page column 259; 314
(2008/12/05)
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- Application of the B-alkyl Suzuki-Miyaura cross-coupling reaction to the stereoselective synthesis of analogues of (3S)-oxidosqualene
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(Chemical Equation Presented) A general method is described for the direct and stereoselective synthesis of epoxypolyenes via Suzuki-Miyaura cross-coupling reaction of 1-iodoalkenes with B-alkylboron compounds. It allows for the straightforward and conver
- Winne, Johan M.,Guang, Bing,D'Herde, Jo,De Clercq, Pierre J.
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p. 4815 - 4818
(2007/10/03)
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- Tetrahydrobenzazepines and their use
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The invention relates to tetrahydrobenzazepines of the general formula I in which the variables Ar, A, B, Y, R1 and R2 have the meaninigs indicated in claim 1, as well as the N-oxides of these compounds, the physiologically tolerated acid addition salts of these compounds and the physiologically tolerated acid addition salts of the N-oxides. The invention also relates to a pharmaceutical compositon that comprises at least one tetrahydrobenzazepine compound of the formula I, the physically tolerated acid addition salt of I, the N-oxide of compound of the formula I and/or the physically tolerated acid addition salts of the N-oxides of I, and further to the use of a compound according to the present invention for treating disorders that respond benefically to dopamine D3 receptor antagonists or dopamine D3 agonists. The compounds according to the invention are preferably useful for the treatment of disorders of the central nervous system such as schizophrenia and depression and for the treatment of renal function disorders.
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Page/Page column 11-12
(2008/06/13)
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- Synthesis of diastereomerically enriched cyclic homoallylic alcohols using molybdenum π-allyl complexes
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Condensation of CpMo(NO)(π-allyl)I complexes bearing a tethered aldehyde gave cyclic homoallylic alcohols with a varying degree of diastereoselectivity. Cyclohexyl and tetrahydronaphthyl derivatives were prepared in moderate to good yields. The diastereos
- Krafft, Marie E.,Schmidt, Peter
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p. 2723 - 2732
(2007/10/03)
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- A New General Synthesis of Polycyclic Aromatic Compounds Based on Enamine Chemistry
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Alkylation of enamines and enamine salts by benzylic and (β-haloethyl)aryl halides, respectively, followed by acidic cyclodehydration and dehydrogenation provides an efficient synthetic approach to a wide range of polycyclic aromatic compounds of diverse structural types.Specific polycyclic hydrocarbons synthesized by this route include benzo- and benzofluorene, 7H-dibenzo-, 13H-dibenzo-, and 13H-dibenzofluorene, 15H-tribenzofluorene, dibenzochrysene, benzopentaphene, indenofluorene, fluorenofluorene, octahydrodibenzanthracene, dibenzanthracene, octahydrodibenzanthracene, dibenzanthracene, picene, benzopicene, 1H-benzaceanthrylene, and 4H-cyclopentachrysene.This method with appropriate modifications appears to be potentially broader in scope than established traditional methods of polycyclic hydrocarbon synthesis.
- Harvey, Ronald G.,Pataki, John,Cortez, Cecilia,Raddo, Pasquale Di,Yang, ChengXi
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p. 1210 - 1217
(2007/10/02)
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- Predicting the stability of cyclic disulfides by molecular modeling: "Effective concentrations" in thiol-disulfide interchange and the design of strongly reducing dithiols
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We have tested molecular mechanics calculations at the level of MM2(85) for their capacity to rationalize relationships between structure and equilibrium constants for thiol-disulfide interchange reactions. With 20 α,ω-dithiols taken from the literature, equilibrium constants for thiol-disulfide interchange with 1,2-dithiane were calculated: HSRSH + S(CH2)4S → SRS + HS(CH2)4SH. The relation between experimental values of ΔG and calculated differences in strain energy was ΔG = 0.41ΔSE + 0.5 kJ/mol with a correlation coefficient of 0.93 (excluding one anomalous point). Results from molecular mechanics correlate well with experimental results, but they cannot give absolute values of energies. Results of molecular mechanics calculations are used to discuss the physical interpretation of the concept of "effective concentration" as it is used for the thiol-disulfide interchange reaction.
- Burns, John A.,Whitesides, George M.
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p. 6296 - 6303
(2007/10/02)
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- THE ANOMERIC EFFECT IN SEVEN-MEMBERED RINGS: A CONFORMATIONAL STUDY OF 1-OXA AND 3-OXA DERIVATIVES OF BENZOCYCLOHEPTENE BY NMR
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The 2-methoxy derivatives 5 and 7 of 3- and 1-benzoexepins (4 and 6 respectively) have been investigated by (13)C and (1)H dynamic NMR methods.The results reveal the presence of two conformer, Ca and Ce (94:6), for 5 due to a strong
- Desilets, S.,St-Jacques, M.
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p. 7027 - 7036
(2007/10/02)
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