- Fluorescent, synthetic amphiphilic heptapeptide anion transporters: Evidence for self-assembly and membrane localization in liposomes
-
Synthetic anion transporters (SATs) of the general type (n-C 18H37)2N-COCH2OCH 2CO-(Gly)3-Pro-(Gly)3-O-n-C7H 15, 1, are amphiphilic peptides that form anion
- You, Lei,Gokel, George W.
-
scheme or table
p. 5861 - 5870
(2009/05/31)
-
- Cation dependence of chloride ion complexation by open-chained receptor molecules in chloroform solution
-
Seventeen peptides, most having the sequence GGGPGGG, but differing in the C- and N-terminal ends, have been studied as anion-complexing agents. These relatively simple, open-chained peptide systems interact with both chloride and the associated cation. Changes in the N- and C-terminal side chains appear to make little difference in the efficacy of binding. NMR studies suggest that the primary interactions involve amide NH contacts with the chloride anion, and CD spectral analyses suggest a concomitant conformational change upon binding. Changes in binding constants, which are expected in different solvents, also suggest selective solvent interactions with the unbound host that helps to preorganize the open-chained peptide system. Significant differences are apparent in complexation strengths when the heptapeptide chain is shortened or lengthened or when the relative position of proline within the heptapeptide is varied.
- Pajewski, Robert,Ferdani, Riccardo,Pajewska, Jolanta,Li, Ruiqiong,Gokel, George W.
-
p. 18281 - 18295
(2007/10/03)
-
- Synthesis, radiolabelling and biological evaluation of terminal oxamide derivatives of mercaptoacetyltriglycine
-
99mTc-MAG3 is widely used in clinical nuclear medicine as a potential replacement of 131I-OIH for renal function studies. The terminal carbonylglycine in the MAG3 backbone is assumed to be essential for maintain
- Okarvi,Torfs,Adriaens,Verbruggen
-
p. 407 - 421
(2007/10/03)
-