PREPARATION OF STEREOCHEMICALLY PURE OXIMES WITH MUSCARINIC ACTIVITY
The instant invention is a selective formation of the Z-oxime and O-alkylation of 1-azabicyclo[2.2.1]heptan-3-one and 1-azabicyclo[2.2. 2] heptan-3-one oximes to produce compounds with muscarinic activity. The process is capable of scale-up for industrial purposes as it provides better yields and ease of preparation. Intermediates are also described.
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(2008/06/13)
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