- Spectroscopic experiments on the role of Me3SiCI in lithium dialkylamide deprotonations
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Low temperature 1H and 7Li NMR studies on LDA and LTMP in the presence of TMS-Cl implicate this additive as a finite source of LiCl, a key component of in situ quenching reactions of ketones.
- Lipshutz, Bruce H.,Wood, Michael R.,Lindsley, Craig W.
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Read Online
- Frustrated Lewis pairs: Reactivities of TMS protected amines and phosphines in the presence of B(C6F5)3
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TMS protected amines in combination with B(C6F5) 3 were found to activate H2 and this is followed by a cleavage of the N-Si bond and the generation of TMSH. A TMS protected phosphine on the other hand reacts rap
- Schulz, Felix,Sumerin, Victor,Leskelae, Markku,Repo, Timo,Rieger, Bernhard
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supporting information; experimental part
p. 1920 - 1922
(2010/05/15)
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- 2',5'-phosphorothioate/phosphodiester oligoadenylates and anti-viral uses thereof
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Optically active antiviral compounds having the formula STR1 wherein m is 0, 1, 2, or 3; n and q are selected from the group of 0 and 1, provided that n and q may not both be zero; and R, R1, and R2 are independently of each other selected from the group consisting of oxygen and sulfur, provided that all R, R1 and R2, may not be oxygen, and further provided that all R, R1, and R2 may not be sulfur. The compounds possess increased antiviral activity and/or metabolic stability.
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- Alkylation and Aldol Reactions of Aldoxime Anions
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The reaction of Z aldoximes with BuLi to give dianions and the properties of the latter were examined.D-Labelling and silylation confirm previous findings that only the Z isomer forms the dianion.Z-Hexanal oxime and Z-octanal oxime were deprotonated with BuLi, and the anions underwent aldol condensation reactions with several aldehydes and ketones including α, β-unsaturated aldehydes.Attempts to alkylate monoanions of OTHP ethers of aldoximes failed.However, carbanion addition to the C=N bond of some oxime OTHP ethers was observed.
- Hassner, Alfred,Naeumann, Fritz
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p. 1823 - 1826
(2007/10/02)
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- 19-Hydroxy-PGI2 compounds
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Prostacyclin and prostacyclin-type derivatives having a 19-hydroxy feature are disclosed, including processes for preparing them and the appropriate intermediates. The compounds are useful for pharmacological purposes such as inhibition of blood platelate aggregation.
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- 2-Decarboxy-2-hydroxymethyl-19-hydroxy-PG1 analogs
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Prostaglandin derivatives having a 19,20-didehydro, a 19-hydroxy, or a 19-keto feature are disclosed, including processes for preparing them and the appropriate intermediates. A typical 19-hydroxy compound of this invention is 19-hydroxy-19-methyl-PGF2α, methyl ester, represented by the formula STR1
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- Bicyclic lactones
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Process for preparing bicyclic lactone acrylic aldehydes and ketones of the formula STR1 wherein "n" is one or 2, wherein R1, is hydrogen, methyl, or ethyl, and wherein R4 is hydrogen or a blocking group; and those aldehydes, ketones, and intermediates prepared therein. The aldehydes and ketones are useful intermediates in preparing prostaglandins and analogs having pharmacological utility.
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