cas 176433-49-1, 2,5-Dichloronicotinaldehyde | Articles data ｜lookchem

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176433-49-1

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Methods of using piperazine derivatives
The present invention relates to compounds of the formula I and the pharmaceutically acceptable forms thereof; wherein X, Y, a, b, c, d, R1, R2, R3, R4 and R5 are as defined herein. Moreover, the present invention is also directed at pharmaceutical compositions comprising a compound of the formula I and a pharmaceutically acceptable carrier. Furthermore, the present invention is directed at methods of using the herein described compounds and compositions for treating or preventing a disorder or condition that can be treated or prevented by antagonizing the CCR1 receptor in a mammal.
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(2008/06/13)

Process for the preparation of 2-halogenopyridinealdehydes and novel 2-halogenopyridinealdehydes
The reaction of cyanoolefins, aminocarbonylolefins or hydroxyiminoolefins with a Vilsmeier reagent leads to 2-halogenopyridines which bear aldehyde groups in the 3 and/or 5 position. These pyridinealdehydes are valuable intermediates for the preparation of pharmaceuticals and crop protection agents.
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(2008/06/13)

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Chemical Properties

Melting Point: 89-92 °C
Boiling Point: 256.283 °C at 760 mmHg
Flash Point:108.796 °C
Density: 1.489 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.016mmHg at 25°C
Refractive Index: 1.608
PKA: -3.75±0.10(Predicted)
PSA: 29.96000
LogP: 2.20090

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