Inhibition of DNA topoisomerase II by azaelliptitoxins functionalized in the variable substituent domain
A series of novel C11-substituted derivatives of azaelliptitoxin (azatoxin) have been synthesized and tested for their inhibitory activity against human DNA topoisomerase II. Incorporation of a C11 polyamine or amine resulted in an i
Tepe, Jetze J.,Madalengoitia, Jose S.,Slunt, Kelli M.,Werbovetz, Karl W.,Spoors, P. Grant,Macdonald, Timothy L.
p. 2188 - 2196
(2007/10/03)
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