- Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
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Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
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- SYNTHESIS OF 2,2'-(ADAMANTYLENE-1,3)-DIETHANOIC ACIDS
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Via direct oxidative addition of 1,1-dichloroethylene to adamantane or 1,3-dimethyladamantane one obtains diethanoic acids of the adamantane series, which are useful in themselves or for preparation of other functional derivatives.Optimal reaction conditions were found by mathematical modeling.Keywords: synthesis, adamantane, dimethyladamantane, 1,1-dichloroethylene, 1,3-bis(carboxymethyl)adamantane, 1,3-bis(carboxymethyl)-5,7-dimethyladamantane, mathematical planning.
- Butenko, L. N.,Novakov, I. A.,Radchenko, S. S.,Kuznechikov, O. A.,Oglodina, T. Yu.,et al.
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p. 1244 - 1246
(2007/10/02)
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- A CONVENIENT SYNTHESIS OF 1,3-DIVINYLADAMANTANE
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1,3-Divinyladamantane was prepared in 30percent overall yield by LiAlH4 reduction of 1,3-bis(carboxymethyl)adamantane, conversion of the resulting diol to the borate ester, and pyrolysis of the ester in vacuo.
- Majerski, Zdenko,Skare, Danko,Vulic, Ljubica
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- SYNTHESIS OF FUNCTIONAL DERIVATIVES OF TRICYCLIC HYDROCARBONS
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The synthesis of carboxylic derivatives of the tricyclic hydrocarbons adamantane and trimethylenenorbornane by the treatment of the hydrocarbons with formic acid and vinylidene chloride in a mixture of sulfuric and nitric acid is described.
- Butenko, L. N.,Protopopov, P. A.,Derbisher, V. E.,Khardin, A. P.
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p. 113 - 120
(2007/10/02)
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