- Continuous synthesis method of succinate (by machine translation)
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The invention discloses a method for continuously synthesizing succinic acid, which is designed according to 3D printing technology, and sequentially combines the chlorination, hydrolysis, condensation, salt forming and refining steps of 4 -acetylamino -2, 3 -dihydrobenzofuran -7 - methyl formate into each reaction chamber to realize the continuous synthesis of drugs. To the method, tedious manual operation is not needed, chemical synthesis is carried out rapidly, the yield of a synthetic route is improved in a flowing chemical manner, and the safety problem caused by manual operation is avoided. The method provided by the invention can greatly reduce the cost generated in the aspects of drug storage, transportation and the like, thereby improving the medicine supply efficiency and stability, and bringing great economic and social benefits for the development of the pharmaceutical industry. (by machine translation)
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Paragraph 0033; 0037-0039; 0043-0045; 0049-0051; 0055-0057
(2020/09/16)
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- PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES
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Provided herein are purification processes for the preparation of highly pure prucalopride succinate salt. Provided also herein are improved, commercially viable and industrially advantageous processes for the preparation of Prucalopride and its intermediate compounds, for example, methyl 4-acetylamino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylate and alkyl 4-[[(4-amino-5-chloro-2,3-dihydro-7-benzofuranyl)carbonyl]-amino]-1-piperidinecarboxylate.
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Page/Page column 29
(2017/09/05)
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- A process for the preparation of intermediate the Pu card must benefit new process (by machine translation)
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The invention discloses a compound of formula (I) indicated by the 1 - (3 - a oxygen propyl) - 4 - amino piperdine preparation method, it includes such as the following steps: (1) a compound of formula (II) in the reaction in a solution of ammonia the system results in the type (III) compound; (2) the compound of formula (III) with 1, 3 - dibromo - 5, 5 - dimethyl hydantoin in the reaction under alkaline condition is the system results in the type (I) compound. This preparation method without special reaction equipment requirements, the operation is simple, and is suitable for industrial production; high yield, three wastes, low cost; high purity, heavy metal residue problem. (by machine translation)
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