- Donor-acceptor-donor-type liquid crystal with a pyridazine core
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(Chemical Equation Presented) A new liquid crystalline material having an ethylenedioxythiophene-pyridazine-ethylenedioxythiophene (EDOT-PDZ-EDOT) core with two peripheral long alkyl chains was prepared. The designated donor-acceptor-donor (D-A-D)-type core structure induced a distinct smectic liquid crystalline phase due to the strong intermolecular interaction. The photophysical property and the layer structure of the liquid crystal were investigated by differential scanning calorimetry, polarized light microscopy, X-ray diffraction, and cyclic voltammetry.
- Yeon, Sil Park,Kim, Dohyung,Lee, Hoosung,Moon, Bongjin
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- Pyridazine N-Oxides as Photoactivatable Surrogates for Reactive Oxygen Species
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A method for the photoinduced evolution of atomic oxygen from pyridazine N-oxides was developed. This underexplored oxygen allotrope mediates arene C-H oxidation within complex, polyfunctional molecules. A water-soluble pyridazine N-oxide was also developed and shown to promote photoinduced DNA cleavage in aqueous solution. Taken together, these studies highlight the utility of pyridazine N-oxides as photoactivatable O(3P) precursors for applications in organic synthesis and chemical biology.
- Basistyi, Vitalii S.,Frederich, James H.
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supporting information
p. 1907 - 1912
(2022/03/27)
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- The difference in the CO2adsorption capacities of different functionalized pillar-layered metal-organic frameworks (MOFs)
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The excessive use of fossil energy has caused the CO2concentration in the atmosphere to increase year by year. MOFs are ideal CO2adsorbents that can be used in CO2capture due to their excellent characteristics. Studies of the structure-activity relationship between the small structural differences in MOFs and the CO2adsorption capacities are helpful for the development of efficient MOF-based CO2adsorbents. Therefore, a series of pillar-layered MOFs with similar structural and different functional groups were designed and synthesized. The CO2adsorption tests were carried out at 273 K to explore the relationship between the small structural differences in MOFs caused by different functional groups and the CO2adsorption capacities. Significantly, compound6which contains a pyridazinyl group has a 30.9% increase in CO2adsorption capacity compared to compound1with no functionalized group.
- Gao, Xiang-Jing,Zheng, He-Gen
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supporting information
p. 9310 - 9316
(2021/07/12)
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- One-Pot and Two-Chamber Methodologies for Using Acetylene Surrogates in the Synthesis of Pyridazines and Their D-Labeled Derivatives
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Acetylene surrogates are efficient tools in modern organic chemistry with largely unexplored potential in the construction of heterocyclic cores. Two novel synthetic paths to 3,6-disubstituted pyridazines were proposed using readily available acetylene surrogates through flexible C2 unit installation procedures in a common reaction space mode (one-pot) and distributed reaction space mode (two-chamber): (1) an interaction of 1,2,4,5-tetrazine and its acceptor-functionalized derivatives with a CaC2?H2O mixture performed in a two-chamber reactor led to the corresponding pyridazines in quantitative yields; (2) [4+2] cycloaddition of 1,2,4,5-tetrazines to benzyl vinyl ether can be considered a universal synthetic path to a wide range of pyridazines. Replacing water with D2O and vinyl ether with its trideuterated analog in the developed procedures, a range of 4,5-dideuteropyridazines of 95–99% deuteration degree was synthesized for the first time. Quantum chemical modeling allowed to quantify the substituent effect in both synthetic pathways.
- Ananikov, Valentine P.,Ledovskaya, Maria S.,Polynski, Mikhail V.
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p. 2286 - 2297
(2021/07/20)
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- Self-assembly of 3,6-bis(4-triazolyl)pyridazine ligands with copper(I) and silver(I) ions: Time-dependant 2D-NOESY and ultracentrifuge measurements
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Two 3,6-bis(R-1H-1,2,3-triazol-4-yl)pyridazines (R=mesityl, monodisperse (CH2-CH2O)12CH3) were synthesized by the copper(I)-catalyzed azide-alkyne cycloaddition and self-assembled with tetrakis(acetonitrile)copp
- Happ, Bobby,Pavlov, Georges M.,Altuntas, Esra,Friebe, Christian,Hager, Martin D.,Winter, Andreas,Goerls, Helmar,Guenther, Wolfgang,Schubert, Ulrich S.
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scheme or table
p. 873 - 880
(2011/10/08)
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- Substituted pyridazines and fused pyridazines with angiogenesis inhibiting activity
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Substituted and Fused pyridazines having angiogenesis inhibiting activity and the generalized structural formula wherein the ring containing A, B, D, E, and L is a nitrogen-containing heterocycle; groups X and Y may be any of a variety of defined linking units; R1 and R2 may be defined independent substituents or together may be a ring-defining bridge; ring J may be an aryl, pyridyl, or cycloalkyl group; and G groups may be any of a variety of defined substituents. Pharmaceutical compositions containing these materials, and methods of treating a mammal having a condition characterized by abnormal angiogenesis or hyperpermiability processes using these materials are also disclosed.
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Page/Page column 48
(2010/02/11)
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- SUBSTITUTED (AMINOIMINOMETHYL OR AMINOMETHYL) BENZOHETEROARYL COMPOUNDS
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This invention is directed to an (aminoiminomethyl or aminomethyl) benzoheteroaryl compound of formula I which is useful for inhibiting the activity of Factor Xa by combining said compound with a composition containing Factor Xa. The present invention is also directed to compositions containing compounds of the formula I, methods for their preparation, their use, such as in inhibiting the formation of thrombin or for treating a patient suffering from, or subject to, a disease state associated with a physiologically detrimental excess amount of thrombin.
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- Fungicidal pyridazines
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Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is
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