Substituted dipeptides having nos inhibiting activity
The present invention a compound represented by the formula (I): where the structural variables R1-R6are defined herein.
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Page column 23
(2010/02/09)
Nickel-catalysed selective N-arylation or N,N′-diarylation of secondary diamines
The selective synthesis of N-aryl or N,N′-diaryl piperazines and trimethylene(bis)piperidines from the corresponding diamines and aryl chlorides using a catalyst combination of Ni(0) associated to 2,2′-bipyridine is described. The Ni/2,2′-bipyridine catalyst is also effective for the sequential arylation of piperazine. The preparation of novel and unsymmetrical 1,4-diaryl piperazines is reported.
Brenner, Eric,Schneider, Rapha?l,Fort, Yves
p. 6913 - 6924
(2007/10/03)
Synthesis of arylpiperazines via palladium-catalyzed aromatic amination reaction with unprotected piperazines
A series of arylpiperazines were synthesized in moderate to good yields by palladium-catalyzed coupling reaction of aryl halides with unprotected piperazines. Very high regioselectivities were observed when using 2-methyl or 2,6-dimethylpiperazine.
Zhao, Shu-Hai,Miller, Aubry K.,Berger, Jacob,Flippin, Lee A.
p. 4463 - 4466
(2007/10/03)
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