Substituted piperidine amide derivative, preparation method thereof, and application of derivative to pharmacy
The invention relates to a substituted piperidine amide derivative as shown in a general formula (I) or a stereisomer and pharmaceutically acceptable salt thereof, a preparation method of the derivative, medicinal combination as well as application of the derivative to the aspects of local anaesthesia or analgesia. The definition of each group of the general formula (I) is consistent with that of the description. (The general formula (I) is as shown in the description).
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Paragraph 0191; 0206; 0207; 0208; 0209; 0210
(2017/08/30)
Metal-free C-N bond-forming reaction: Straightforward synthesis of anilines, through cleavage of aryl C-O bond and amide C-N bond
An efficient metal-free C-N bond forming reaction through cleavage of aryl C-O bond and amide C-N bond has been developed. This process represents a practical method for the facile construction of anilines with a broad substrate scope and wide functional group tolerance in moderate to excellent yields.
Yu, Jianzhong,Zhang, Peizhi,Wu, Jun,Shang, Zhicai
supporting information
p. 3167 - 3170
(2013/06/27)
Preparation of primary aromatic amines from cyclic alcohols and/or ketones
Aromatic amines, in particular substituted amines, are obtained from corresponding alicyclic alcohols or ketones, in one step, by amination and dehydrogenation with ammonia in the presence of hydrogen and of a palladium catalyst which also contains zinc or cadmium.
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(2008/06/13)
Synthesis of trimethylhydroquinone from p-xylene.
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Sato,Fujima,Yamada
p. 442 - 444
(2007/10/06)
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