- 4-fluoronaphthalene-1-alcohol preparation technology
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The invention discloses a 4-fluoronaphthalene-1-alcohol preparation technology. The preparation technology takes 1-fluoronaphthalene as a raw material, the raw material is subjected to halogenation, boration and hydrolysis to obtain the 4-fluoronaphthalene-1-alcohol, and the overall yield can reach 60%. The technology has the advantages of low cost and easy acquisition of the raw materials, simple and easy operation of post-treatment t, high yield, and easy industrial application.
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Paragraph 0043; 0044; 0045; 0067; 0068; 0069
(2017/08/26)
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- Organic compound for organic electroluminescent device
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The present invention discloses a novel organic compound is represented by the following formula(A), the organic EL device employing the compound as blue emitting layer can lower driving voltage, prolong half-lifetime and increase the efficiency. Wherein
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Page/Page column
(2015/06/09)
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- Structure-Activity Relationships of Potent, Selective Inhibitors of Neuronal Nitric Oxide Synthase Based on the 6-Phenyl-2-aminopyridine Structure
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The synthesis and structure-activity relationships of a series of 6-phenyl-2-aminopyridines that potently and selectively inhibit the neuronal isoform of nitric oxide synthase (nNOS) are described. Compound 14bi from this series exhibits potent in vivo activity in harmaline-induced cGMP formation in rat cerebellum, a functional model of nNOS inhibition, and in the PCP-induced hypermotility model in the rat. These results suggest that 14bi may be a useful reagent for evaluating potential therapeutic applications of nNOS inhibitors in the central nervous system.
- Lowe III, John A.,Qian, Weimin,Drozda, Susan E.,Volkmann, Robert A.,Nason, Deane,Nelson, Robert B.,Nolan, Charles,Liston, Dane,Ward, Karen,Faraci, Steve,Verdries, Kim,Seymour, Pat,Majchrzak, Michael,Villalobos, Anabella,White, W. Frost
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p. 1575 - 1586
(2007/10/03)
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- 2-aminopyridines containing fused ring substituents
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The present invention relates to 2-aminopyridine derivatives of the formula I: or pharmaceutically acceptable salts thereof, whereinA and B are each independently H, or together, A and B form a ring fused to the phenyl ring, said ring being saturated or unsaturated and containing from 5 to 7 ring member atoms, where said ring member atoms may optionally comprise from 1 to 2 heteroatoms selected independently from the group consisting of N, O or S, provided that no two adjacent ring members are heteroatoms;X is oxygen or a single bond;Y is (C1-C6)alkyl;R1 is hydrogen, (C1-C6)alkyl or a (C1-C6 alkyl) group substituted with —NR2R3 wherein R2 and R3 are either selected independently from the group consisting of H, alkyl, aryl, aralkyl or tetrahydronaphthalene, wherein said aryl group or said aryl moiety of said aralkyl group is phenyl or naphthyl, said alkyl group or said alkyl moiety of said aralkyl group contains from one to six carbon atoms and is straight-chained or branched, and said aryl group, said tetrahydronaphthalene or said aryl moiety of said aralkyl group is optionally substituted with from one to three of halogen, nitro, cyano, amino, (C1-C4)alkoxy and (C1-C4)alkylamino moieties, or R2 and R3 form, together with the nitrogen to which they are attached, a heterocyclic ring, or a cyclic or bicyclic ring which is saturated or unsaturated. The compounds of the invention have the ability to inhibit the activity of nitric oxide synthases (NOS), and hence, are useful in the treatment of diseases, conditions and disorders of the central nervous system, among others.
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- 2-aminopyridines containing fused ring substituents
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The present invention relates to 2-aminopyridine derivatives of the formula wherein G, R1 and R2 are defined as in the specification, that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
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