- Stereospecific (Conrotatory) Photochemical Ring Opening of Alkylcyclobutenes in the Gas Phase and in Solution. Ring Opening from the Rydberg Excited State or by Hot Ground State Reaction?
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The photochemistry of 1,2-dimethylcyclobutene and cis- and trans-1,2,3,4-tetramethylcyclobutene has been studied in the gas phase (1 atm; SF6 buffer) and in hydrocarbon solvents with 193-, 214-, and 228-nm light sources. The major products are the isomeric dienes from electrocyclic ring opening and 2-butyne + alkene (ethylene or E-/Z- 2-butene) due to formal [2+2]-cycloreversion. The total yields of dienes relative to 2-butyne are generally higher in the gas phase than in solution but decrease with increasing excitation wavelength under both sets of conditions. In the case of cis-1,2,3,4-tetramethylcyclobutene, 228-nm photolysis results in the stereospecific formation of E,Z-3,4-dimethyl-2,4-hexadiene - the isomer corresponding to ring opening by the thermally allowed (conrotatory) electrocyclic pathway - in both the gas phase and solution. All three diene isomers are obtained upon 228-nm photolysis of trans-1,2,3,4-tetramethylcyclobutene, but control experiments suggest that the thermally allowed isomers (E,E- and Z,Z-3,4-dimethyl-2,3-hexadiene) are probably the primary products in this case as well. The results are consistent with cycloreversion resulting from excitation of the low-lying π,R(3s) singlet state and with ring opening proceeding by at least two different mechanisms depending on excitation wavelength. The first, which dominates at short wavelengths, is thought to involve direct reaction of the second excited singlet (π,π*) state of the cyclobutene. The second mechanism, which dominates at long wavelengths, is proposed to ensue either directly from the lowest energy (Rydberg) state or from upper vibrational levels of the ground state, populated by internal conversion from this excited state.
- Leigh, William J.,Cook, Bruce H. O.
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- Replacing conventional carbon nucleophiles with electrophiles: Nickel-catalyzed reductive alkylation of aryl bromides and chlorides
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A general method is presented for the synthesis of alkylated arenes by the chemoselective combination of two electrophilic carbons. Under the optimized conditions, a variety of aryl and vinyl bromides are reductively coupled with alkyl bromides in high yields. Under similar conditions, activated aryl chlorides can also be coupled with bromoalkanes. The protocols are highly functional-group tolerant (-OH, -NHTs, -OAc, -OTs, -OTf, -COMe, -NHBoc, -NHCbz, -CN, -SO2Me), and the reactions are assembled on the benchtop with no special precautions to exclude air or moisture. The reaction displays different chemoselectivity than conventional cross-coupling reactions, such as the Suzuki-Miyaura, Stille, and Hiyama-Denmark reactions. Substrates bearing both an electrophilic and nucleophilic carbon result in selective coupling at the electrophilic carbon (R-X) and no reaction at the nucleophilic carbon (R-[M]) for organoboron (-Bpin), organotin (-SnMe3), and organosilicon (-SiMe2OH) containing organic halides (X-R-[M]). A Hammett study showed a linear correlation of σ and σ(-) parameters with the relative rate of reaction of substituted aryl bromides with bromoalkanes. The small ρ values for these correlations (1.2-1.7) indicate that oxidative addition of the bromoarene is not the turnover-frequency determining step. The rate of reaction has a positive dependence on the concentration of alkyl bromide and catalyst, no dependence upon the amount of zinc (reducing agent), and an inverse dependence upon aryl halide concentration. These results and studies with an organic reductant (TDAE) argue against the intermediacy of organozinc reagents.
- Everson, Daniel A.,Jones, Brittany A.,Weix, Daniel J.
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supporting information; experimental part
p. 6146 - 6159
(2012/05/07)
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- Conrotatory photochemical ring opening of alkylcyclobutenes in solution. A test of the hot ground-state mechanism
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Quantum yields for photochemical ring opening of six alkylcyclobutenes have been measured in hexane solution using 228-nm excitation, which selectively populates the lowest π,R(3s) excited singlet states of these molecules and has been shown previously to lead to ring opening with clean conrotatory stereochemistry. The compounds studied in this work - 1,2-dimethylcyclobutene (1), cis- and trans-1,2,3,4-tetramethylcyclobutene (cis- and trans-5), hexamethylcyclobutene (8), and cis- and trans-tricyclo[6.4.0.02,7]dodec-12-ene (cis- and trans-9) - were selected so as to span a broad range in molecular weight and as broad a range as possible in Arrhenius parameters for thermal (ground-state) ring opening. RRKM calculations have been carried out to provide estimates of the rate constants for ground-state ring opening of each of the compounds over a range of thermal energies from 20 00O to 49 000 cm-1. These have been used to estimate upper limits for the quantum yields of ring opening via a hot ground-state mechanism, assuming a value of kdeact = 1011 s-1 for the rate constant for collisional deactivation by the solvent, that internal conversion to the ground state from the lowest Rydberg state occurs with close to unit efficiency, and that ergodic behavior is followed. The calculated quantum yields are significantly lower than the experimental values in all cases but one (1). This suggests that the Rydberg-derived ring opening of alkylcyclobutenes is a true excited-state process and rules out the hot ground-state mechanism for the reaction.
- Cook,Leigh,Walsh
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p. 5188 - 5193
(2007/10/03)
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- Cyclobutene photochemistry. Steric effects on the photochemical ring opening of alkylcyclobutenes
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Quantum yields for photochemical ring opening and cycloreversion in hydrocarbon solution have been determined for the direct photolysis (214 nm) of six 1,2-dimethylcyclobutene derivatives which contain methyl groups at C3, and C4 in numbers varying from zero to four. As the hydrogens on C3/C4 of the parent compound (1,2-dimethylcyclobutene) are replaced with increasing numbers of methyl groups, the total quantum yield for ring opening increases to a maximum of ~0.3 and then decreases with further methyl substitution. The quantum yields for ring opening (φtotal) of hexamethylcyclobutene and 1,2-dimethylcyclobutene are nearly the same, and the lowest in the series. The maximum occurs with trans-1,2,3,4-tetramethylcyclobutene; φtotal for the cis-isomer is significantly lower, but both yield an approximate 1:1 mixture of formally allowed and forbidden diene isomers. A similar trend is observed in the relative quantum yields for ring opening and cycloreversion throughout the series. The results are interpreted in terms of a combination of bond strength and steric effects on the efficiency of the ring-opening process. Increasing methyl substitution causes an increase in φtotal through the first three members of the series owing to progressive weakening of the C3-C4 bond. Compounds containing cis-dimethyl substitution exhibit substantially reduced quantum yields for ring opening, relative to what would be expected based on bond strength effects alone. This is proposed to be due to steric effects on the efficiency of the process, suggesting that the initial stages of the photochemical ring opening of cyclobutene involve disrotatory motions on the excited singlet state potential energy surface.
- Leigh, William J.,Postigo, J. Alberto
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p. 1688 - 1694
(2007/10/02)
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- Cyclobutene photochemistry. Substituent and wavelenght effects on the photochemical ring opening of monocyclic alkylcyclobutenes
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The photochemical ring opening of cis- and trans-3,4-dimethyl-, 1,3,4-trimethyl-, and 1,2,3,4-tetramethylcyclobutene (1,3, and 4, respectively) has been investigated in hydrocarbon solution with 193 nm and 214 nm light sources.Ring opening is non-stereospecific in all cases at both wavelenghts.The ratio of dienes formed by the formally allowed to formally forbidden pathways in the photolysis of these compounds is highest (ca. 2) for the trimethylcyclobutenes, and approximately 1 for both cis and trans isomers of the di- and tetramethylcyclobutenes with 193 nm excitation.The diene distributions from photolysis of all compounds but cis-3 show slight wavelength dependence.Gas- and solution-phase UV absorption spectra are reported for 3 and 4, and indicate that there are at least three singlet excited states accessible in the 185-230 nm region in these molecules.The ?,R(3s) state is the lowest energy state in the gas phase in 3 and 4.The results verify that orbital symmetry factors do not play a role ( or a consistent one, at least) in controlling the stereochemistry of the reaction, but they do not allow a firm assignment of the excited state(s) responsible for ring opening.Direct photolysis of these compounds also results in fragmentation to yield Z-2-butene (from cis-3 and 4) or E-2-butene (from trans-3 and 4) in addition to propyne or 2-butyne.The 2-butenes are formed with greater than 90percent stereospecifity in all cases.The structures of the four 3-methyl-2,4-hexadiene isomers obtained from photolysis of 3 have been assigned on the basis of 1H NMR spectroscopy and the results of thermolysis of the two cyclobutene isomers.
- Leigh, William J.,Zheng, Kangcheng,Clark, K. Brady
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p. 1988 - 1997
(2007/10/02)
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