Functionalization of the A ring of pyridoacridine as a route toward greater structural diversity. Synthesis of an octacyclic analogue of eilatin
In an effort to increase the structural diversity of pyrido[4,3,2-kl]acridines, compounds containing amino substituents on the A ring were synthesized. The key-reactions involve regioselective electrophilic aromatic substitutions. The methodology was appl
Synthesis of polyfunctionalized Troger's Base analogs derived from ethacridine (6,9-diamino-2-ethoxyacridine)
In the search for chemical probes of DNA conformations, we report an efficient synthesis of new Troger's Base analogs derived from polyfunctionalized aminoacridines treated with a stoichiometric amount of formaldehyde in trifluoroacetic acid. For the more sensitive aminoacridines, the Troger's Bases were obtained by nucleophilic substitution of the chloro group of the 'pre-formed' corresponding Troger's Base.
Tatibouet,Demeunynck,Lhomme
p. 4375 - 4395
(2007/10/03)
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