- Synthesis of carboxylic amides by ring-opening of oxazolidinones with Grignard reagents
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Treatment of N-alkyl-oxazolidin-2-ones with Grignard reagents gives tertiary carboxylic amide products. Various substituted oxazolidinones can be used as illustrated with phenyl, benzyl or isopropyl groups on the 4-position, and methyl, benzyl or p-methox
- Bensa, David,Coldham, Iain,Feinaeugle, Pia,Pathak, Ravindra B.,Butlin, Roger J.
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scheme or table
p. 1410 - 1415
(2008/10/09)
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- 1,3-Diphenylpropan-1,3-diamines IX. Reaction of α-Chlorooxime Ethers with α-Lithiobenzylamines
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The carbanions of the benzylamine derivatives 1-4 have been reacted with α-chlorooxime ether 5 in order to get precursors of 1,3-diphenylpropane-1,3-diamines.Isonitrile 1 afforded the expected result, whereas lithiated benzamide 2 underwent oxidative dimerization and transmetallated chlorooxime derivative 5.Isoxazolidine 3 gave the condensation product 21 as a mixture of diastereomers; treatment of imine 4 led to the desired amine-oxime 15 in low yield. - Keywords: 1,3-Diphenylpropane-1,3-diamines; Benzylamine carbanions; α-Chloroacetophenone-oxime O-methyl ether
- Kaiser, A.,Wiegrebe, W.
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p. 763 - 774
(2007/10/03)
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