Total synthesis of the serine-threonine phosphatase inhibitor microcystin-LA
Reversible protein phosphorylation, which is mediated by kinases and phosphatases, is a major control element of the cell. There is a diverse group of toxic natural products that inhibit certain phosphatases, thereby disrupting normal biochemical pathways
Humphrey, John M.,Aggen, James B.,Chamberlin, A. Richard