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18436-73-2

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Synthesis and in vitro evaluation of new benzenesulfonamides as antileishmanial agents
This paper describes the synthesis and the antileishmanial activity of new pyrazolyl benzenesulfonamide derivatives. These were elucidated by spectrometric methods. Some compounds showed a significant in vitro activity against Leishmania amazonensis, highlighting the derivative 1e. These pyrazolyl benzenesulfonamide derivatives did not show any toxicity in murine macrophage.
Borges, Julio C.,Carvalho, Adriana V.,Bernardino, Alice M.R.,Oliveira, Ce?sar D.,Pinheiro, Luiz C.S.,Marra, Roberta K.F.,Castro, Helena C.,Wardell, Solange M.S.V.,Wardell, James L.,Amaral, Veronica F.,Canto-Cavalheiro, Marilene M.,Leon, Leonor L.,Genestra, Marcelo
p. 980 - 986
(2014/06/24)

Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities
A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2.
Madrid, Peter B.,Sherrill, John,Liou, Ally P.,Weisman, Jennifer L.,DeRisi, Joseph L.,Guy, R. Kiplin
p. 1015 - 1018
(2007/10/03)

QUINOLYL AMIDE DERIVATIVES AS CCR-5 ANTAGONISTS
The present invention relates to a series of compounds which are CCR-5 receptor antagonists of the general formula (I): or a pharmaceutically acceptable salt thereof, wherein the variables are defined herein.
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Page 30; 31

(2010/02/10)

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Chemical Properties

Boiling Point: 275.6°Cat760mmHg
Flash Point:147°C
Density: 1.225g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Vapor Pressure: 0.008mmHg at 25°C
PSA: 12.89000
LogP: 3.19660

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