- Supramolecular synthesis of 3,4-dihydropyrimidine-2(1H)-one/thiones under neat conditions
-
An efficient solvent free method for the synthesis of various 3,4-dihydropyrimidin-2(1H)-one/thiones in excellent yields using sulfonated β-cyclodextrine as recyclable catalyst is described. Sulfonated β-cyclodextrine was found to be efficient, recyclable
- Asghari, Sekineh,Tajbakhsh, Mahmood,Kenari, Behnam Jafarzadeh,Khaksar, Samad
-
-
Read Online
- Boron trioxide-alumina as a heterogeneous catalyst in a facile solvent free one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones
-
B2O3/Al2O3 has been found to be a new and highly efficient heterogeneous catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones by the Biginelli reaction under solvent-free conditions. 3,4-Dihydropyrimidin-2(1H)-ones have important pharmacological and biological activities.
- Zhou, Xufeng,Cheng, Tianxing,Zheng, Xiangyong,Ke, Qiang,Wang, Xuebao
-
-
Read Online
- Microwave-assisted synthesis of dihydropyrimidin-2(1H)-ones using graphite supported lanthanum chloride as a mild and efficient catalyst
-
Graphite supported lanthanum chloride efficiently catalyzes the three-component coupling of β-ketoesters, aldehydes and urea/thiourea to afford corresponding dihydropyrimidinones in good yields under microwave irradiation.
- Khabazzadeh, Hojatollah,Saidi, Kazem,Sheibani, Hassan
-
-
Read Online
- Poly(N-vinyl-2-pyrrolidone)-supported ferric chloride: An effective reusable heterogeneous catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via three-component Biginelli reaction
-
An environmentally benign three-component Biginelli protocol for the one-pot synthesis of substituted 3,4-dihydropyrimidin-2(1H)-ones/thiones using an accessible, nontoxic, easy to handle, and recoverable macromolecular Lewis acidic catalyst is developed.
- Donyapeyma, Ghazaleh,Rahmatpour, Ali
-
-
- Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones
-
The synthesis of 3,4-dihydropyrimidin-2(1H)-(thio)one (DHPM) derivatives involving aromatic aldehyde, β-ketoesters and urea/thiourea using prolinium hydrogen sulfate (ProHSO4) as a catalyst has been studied. A variety of DHPM derivatives were o
- Patil, Rajendra,Rode, Nitin,Shelar, Amruta,Tantray, Aafaq,Terdale, Santosh
-
supporting information
(2021/12/22)
-
- Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives
-
In this study, for the first time, we have used Citrus macroptera juice to synthesize dihydropyrimidine (DHPM) derivatives via the Biginelli reaction, which showed better yield, shorter reaction time, and did not require an organic solvent for the reactio
- Dowarah, Jayanta,Marak, Brilliant N.,Patel, Devanshi,Shah, Pramod Kumar,Shukla, Pradeep Kumar,Singh, Ved Prakash,Yadav, Umesh Chand Singh
-
p. 35737 - 35753
(2021/12/02)
-
- Aiding the versatility of simple ammonium ionic liquids by the synthesis of bioactive 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives
-
Simple ammonium ionic liquids [ILs] are efficient, green, environmentally friendly catalysts in promoting the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction to afford 1,2,3,4-tetrahydropyrimidine, 2-aminothiazole and quinazolinone derivatives respectively by eliminating the need for harmful volatile organic solvents. These [ILs] are air and water stable, easy to prepare and cost-effective. The effects of the anions and cations present in [IL] on reactions were investigated. The results clearly indicated that the Biginelli condensation reaction, Hantzsch reaction and Niementowski reaction were heavily influenced by the acidity of [IL], and among various ammonium ionic liquids, [Et3NH][HSO4] showed the best catalytic activity. Furthermore, [IL] could be easily separated and reused with a slight loss of its activity. This technique provided a good alternative way for the industrial synthesis of 1,2,3,4-tetrahydropyrimidinones, 2-aminothiazoles and quinazolinones. The present processes are eco-friendly methods for the synthesis of these derivatives authenticated by several green parameters, namely,E-factor, process mass intensity, reaction mass efficiency, atom economy, and carbon efficiency.
- Kakati, Praachi,Singh, Preeti,Yadav, Priyanka,Awasthi, Satish Kumar
-
p. 6724 - 6738
(2021/04/22)
-
- Synthesis method of dihydropyrimidinone compound
-
The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a
- -
-
Paragraph 0034-0036; 0040-0041; 0044; 0070-0075; 0079
(2021/05/19)
-
- Efficient one-pot synthetic methods for the preparation of 3,4-dihydropyrimidinones and 1,4-dihydropyridine derivatives using BNPs?SiO2(CH2)3NHSO3H as a ligand and metal free acidic heterogeneous nano-catalyst
-
Heterocyclic compounds with biological and pharmacological activates like 3,4-dihydropyrimidin-2-(1H)-ones and 1,4-dihydropyridines have attracted great interest. Boehmite nanoparticles functionalized with silylpropyl sulfamic acid (BNPs?SiO2(C
- Bahrami, Kiumars,Khodamorady, Minoo,Sohrabnezhad, Samira
-
-
- Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation
-
Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan
- Godugu, Kumar,Gundala, Trivikram Reddy,Mohinuddin Pinjari, Mohammad Khaja,Reddy Nallagondu, Chinna Gangi,Sanapareddy, Lakshmi Reddy,Sri Yadala, Venkata Divya
-
supporting information
p. 1881 - 1900
(2020/10/02)
-
- Concentrated solar radiation as a renewable heat source for a preparative-scale and solvent-free Biginelli reaction
-
A well-known Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was performed in an environmentally responsible manner. Large numbers of substrates were screened, and found to give excellent yields of the desired products. In
- Gadkari, Yatin U.,Hatvate, Navnath T.,Takale, Balaram S.,Telvekar, Vikas N.
-
supporting information
p. 8167 - 8170
(2020/06/09)
-
- Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions
-
An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq
- Li, Ningbo,Wang, Yijun,Liu, Feijun,Zhao, Xin,Xu, Xinhua,An, Quan,Yun, Keming
-
-
- CoNiFe2O4@Silica-SO3H nanoparticles: New recyclable magnetic nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions
-
A useful and green synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were achieved by one-pot cyclocondensation between substituted aryl aldehydes, diketone/ketoester, and urea/thiourea using magnetic CoNiFe2O4@Silica-
- Karimian, Azam,Rad, Masoud Saadati,Mahdavi, Elham
-
p. 1702 - 1714
(2020/09/07)
-
- Synthesis and characterization of the immobilized polythiophene on magnetic carbon nanotube as a prominent catalyst for the synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives
-
Abstract: In this work, the immobilized polythiophene on magnetic carbon nanotube (CNT–Fe3O4–PTh) was synthesized and introduced as a novel and recoverable catalytic system. The prepared magnetic heterogeneous nanocatalyst was characterized by FT-IR, TGA, EDX, VSM, XRD, TEM, and FE-SEM. Next, the catalytic efficiency of CNT–Fe3O4–PTh was evaluated through the green synthesis of a variety of dihydropyrimidinone and octahydroquinazolinone through Biginelli reaction between aromatic aldehydes, urea/thiourea, and β-dicarbonyl compounds under solvent-free conditions. The catalyst was magnetically recovered and recycled for five cycles without a discernible loss in its catalytic activity. Simple workup, affordability, short reaction times, mild reaction conditions, and the high yield of products are the interesting features of this project. Graphic abstract: An environmentally benign nanocomposite was prepared using carbon nanotube as an inexpensive, nontoxic, and stable support in the preparation of CNT–Fe3O4–PTh, which was efficiently used as catalyst for the green synthesis of dihydropyrimidinone and octahydroquinazolinone derivatives through Biginelli reaction under solvent-free conditions.[Figure not available: see fulltext.].
- Akbarzadeh, Parisa,Koukabi, Nadiya
-
p. 4955 - 4969
(2020/08/19)
-
- Porous organic polymer bearing triazine and pyrene moieties as an efficient organocatalyst
-
Materials with high specific surface area and bearing abundant basic sites at their pore surface are very demanding as heterogeneous catalyst for the eco-friendly base catalyzed reactions. Here we have developed a new secondary amine linked triazine and p
- Bhaumik, Asim,Chakraborty, Debabrata,Chowdhury, Avik,Das, Sabuj Kanti,Kayal, Utpal
-
-
- A nanocrystalline CdS thin film as a heterogeneous, recyclable catalyst for effective synthesis of dihydropyrimidinones and a new class of carbazolyl dihydropyrimidinones: Via an improved Biginelli protocol
-
This is the first report on the use of a nanocrystalline cadmium sulphide (CdS) thin film coated glass reactor as an efficient tool for the synthesis of dihydropyrimidinones via multicomponent reactions of aldehydes, a β-ketoester, and urea/thiourea in et
- Venkatapathy,Magesh,Lavanya,Perumal,Sathishkumar
-
p. 10989 - 11002
(2019/07/15)
-
- Solvent and catalyst free synthesis of 3,4-dihydropyrimidin-2(1: H)-ones/thiones by twin screw extrusion
-
This report describes the synthesis of a few 3,4-dihydropyrimidin-2(1H)-ones/thiones using a twin screw extruder. Use of the extruder allowed the reaction to be carried out without a catalyst or solvent. Twin screw extrusion can also be executed as a cont
- Carvalho, Reyniel Ben,Joshi, Shreerang V.
-
supporting information
p. 1921 - 1924
(2019/04/29)
-
- Preparation method and application of novel ionic salicylaldehyde Schiff base zirconium complex (by machine translation)
-
The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic salicylaldehyde Schiff base zirconium complex. The cationic part is formed by coordination of zi
- -
-
Paragraph 0086-0087
(2019/11/20)
-
- CoFe2O4/TMU-17-NH2 as a hybrid magnetic nanocomposite catalyst for multicomponent synthesis of dihydropyrimidines
-
A new magnetic metal–organic framework nanocomposite (CoFe2O4/TMU-17-NH2) was prepared via an embedding approach by synthesis of the metal–organic framework crystals in the presence of magnetic cobalt ferrite nanoparticles. We demonstrated that the resulting magnetic nanocomposite can serve as a recyclable nanocatalyst for one-pot synthesis of bis-3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidin-2(1H)-one derivatives via three-component reaction of 1,3-diketone, urea or thiourea and aromatic aldehyde under solvent-free conditions. CoFe2O4/TMU-17-NH2 was characterized using various techniques. The recovery of the nanocomposite was achieved by a simple magnetic decantation and it was reused at least seven times without significant degradation in catalytic activity.
- Yadollahi, Mahtab,Hamadi, Hosein,Nobakht, Valiollah
-
-
- Bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles as an efficient and magnetically reusable nano-catalyst for Biginelli-type reaction
-
Abstract: The preparation of bis(p-sulfoanilino)triazine-functionalized silica-coated magnetite nanoparticles and their use as a novel magnetically separable nanocatalyst for the synthesis of various Biginelli adducts are presented. The materials were characterized by various microscopic and spectroscopic techniques such as scanning electron microscopy, vibrating sample magnetometer, X-ray powder diffraction, and FT-IR spectroscopy, etc. A series of 3,4-dihydropyrimidinones or thione products were conveniently prepared by this green protocol from the reactions of aromatic aldehydes with the 1,3-dicarbonyl compounds and urea or thiourea using the catalyst under solvent-free conditions. The present method is operationally simple and offers several advantages such as good to excellent yields, short reaction times, the absence of a solvent, and simple work-up. Moreover, the aforementioned nanocatalyst can be easily recovered from the reaction mixture with the assistance of an external magnetic field and reused several times without any loss of its catalytic activity.
- Moghanian, Hassan,Fard, Mohammad Ali Bodaghi,Mobinikhaledi, Akbar,Ahadi, Najmieh
-
p. 4083 - 4101
(2018/06/19)
-
- Novel pyrimidinic selenourea induces DNA damage, cell cycle arrest, and apoptosis in human breast carcinoma
-
Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and selectivity for tumour cells. Three analogues of 3j were designed and synthesi
- Barbosa, Flavio A.R.,Siminski, Tamila,Canto, R?mulo F.S.,Almeida, Gabriela M.,Mota, Nádia S.R.S.,Ourique, Fabiana,Pedrosa, Rozangela Curi,Braga, Antonio Luiz
-
p. 503 - 515
(2018/06/15)
-
- Br?nsted acidic 1-ethyl-1,2,4-trizolium phenylsulfonate as catalyst for biginelli reaction
-
A Br?nsted acidic 1-ethyl-1,2,4-triazolium phenylsulfonate has been synthesized and characterized. A catalytic study is performed for 1-ethyl-1,2,4-triazolium phenylsulfonate as acid catalyst for a multicomponent reaction of synthesis of series of 3,4-dih
- Puthukkudy,Nagarajan,Kandasamy
-
p. 1999 - 2002
(2018/08/09)
-
- T3P-DMSO mediated one-pot tandem approach for the synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/thiones from alcohols
-
Background: Biginelli reaction is one of the most important multiple-component chemical reactions which creates 3,4-dihydropyrimidin-2(1H)-ones. Even though Biginelli reaction was reported over a century using different substrates, literature lacks the ex
- Vinaya, Kambappa,Shivaramu, Prasanna D.,Chandrashekara, Ganganahalli K.,Chandrappa, Siddappa,Rangappa, Kanchugarakoppal S.
-
p. 241 - 245
(2018/04/20)
-
- A Cu(II) metal-organic framework with significant H2 and CO2 storage capacity and heterogeneous catalysis for the aerobic oxidative amination of C(sp3)-H bonds and Biginelli reactions
-
A Cu(ii) metal-organic framework, {[Cu2(L)(H2O)2]·(5DMF)(4H2O)}n (1), has been synthesized using an angular tetracarboxylic acid ligand (H4L) incorporating both trifluoromethyl (-CF3/
- Gupta, Anoop K.,De, Dinesh,Tomar, Kapil,Bharadwaj, Parimal K.
-
p. 1624 - 1634
(2018/02/09)
-
- Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and α1β2δ GABAA receptors
-
The α4βδ subtype of the γ-aminobutyric acid (GABA) type A receptors (GABAARs) has been shown to be implicated in high-affinity binding of the neuromodulator γ-hydroxybutyric acid (GHB), but may not be the only GHB high-affinity bindi
- Damgaard, Maria,Al-Khawaja, Anas,Nittegaard-Nielsen, Mia,Petersen, Rebekka F.,Wellendorph, Petrine,Fr?lund, Bente
-
p. 300 - 312
(2017/07/06)
-
- Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two novel nanostructured catalysts: applications in the synthesis of Biginelli-type, polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives
-
Abstract: Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two nanostructured novel, green and heterogeneous catalysts were designed, synthesized and fully characterized by FT-IR, energy-dispersive X-ray spectroscopy, X-ray diffraction patterns, scanning electron microscopy, transmission electron microscopy and thermal gravimetric analysis. Then their catalytic applications were studied in the Biginelli-type reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via one-pot three-component condensation reaction between several aldehydes, ethyl acetoacetate and urea or thiourea. To further study catalytic properties of NMSDSA and NMSMSA, they were used in the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives under same reaction conditions. NMSDSA and NMSMSA have advantages such as cost-effectiveness, cleaner reaction profile, benign and heterogeneous characters, reusability of the catalysts and being in agreement with the green chemistry protocols. The described nanostructured catalysts have natural-based acids and potential for industrial production. Graphical Abstract: Synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via Biginelli-type reaction, polyhydroquinolines and 2,3-dihydroquinazolin-4(1H)-ones using NMSDSA and NMSMSA as two novel nanostructured catalysts. [Figure not available: see fulltext.]
- Zolfigol, Mohammad Ali,Ghaderi, Hossein,Baghery, Saeed,Mohammadi, Leila
-
p. 121 - 134
(2017/01/05)
-
- A New Type of Magnetically-Recoverable Heteropolyacid Nanocatalyst Supported on Zirconia-Encapsulated Fe3O4 Nanoparticles as a Stable and Strong Solid Acid for Multicomponent Reactions
-
Abstract: A novel highly efficient magnetically retrievable catalyst was developed by the immobilization of H3PW12O40 (20–60 wt%) on the surface of zirconia-encapsulated Fe3O4 nanoparticles. The prepared HPW supported on nano-Fe3O4@ZrO2 heterogeneous acid catalyst (or n-Fe3O4@ZrO2/HPW) was fully characterized by several physicochemical techniques such as: Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction, vibrating sample magnetometry and thermogravimetric analysis. The FT-IR spectroscopic data revealed that H3PW12O40 molecules on the nano-Fe3O4@ZrO2 support existed in the Keggin structure. The acidity of the catalyst was measured by the help of a potentiometric titration with n-butylamine. It was surprising that this very strong solid acid catalyst exhibited an excellent acid strength which was as a result of possessing a higher number of surface active sites compared to its homogeneous analogues. The catalytic activity of the as-prepared novel nano-Fe3O4@ZrO2/HPW was explored through the one-pot three-component synthesis of different 3,4-dihydropyrimidin-2(1H)-ones (i.e. Biginelli reaction) and 1,4-dihydropyridines (i.e. Hantzsh reaction) under solvent free condition. The sample of 40 wt% showed higher acidity and activity in the catalytic transformation. After the reaction, the catalyst/product isolation could be easily achieved with an external magnetic field and the catalyst could be easily recycled for at least five times without any decrease in its high catalytic activity. The excellent recyclability was attributed to the strong interaction between the hydroxyl groups of the nano-Fe3O4@ZrO2 support and the HPW species. Graphical Abstract: [Figure not available: see fulltext.].
- Zolfagharinia, Somayeh,Kolvari, Eskandar,Koukabi, Nadiya
-
p. 1551 - 1566
(2017/05/17)
-
- Punica granatum peel: an organocatalyst for green and rapid synthesis of 3,4-dihydropyrimidin-2 (1H)-ones/thiones under solvent-free condition
-
A novel and green approach was adopted for the synthesis of 3,4-dihydropyrimidin-2(1H)-one/thiones derivatives using Punica granatum peel as an inexpensive, efficient and mild catalyst under solvent-free condition. The methodology is characterized by high
- Mohammadian, Narges,Akhlaghinia, Batool
-
p. 3325 - 3347
(2017/04/21)
-
- 1-Methyl-2-oxopyrrolidinium perchlorate ionic liquid in synthesis of 5-ethoxycarbonyl-3,4-dihydropyrimidin-2(1H)-ones
-
A multicomponent Biginelli reaction in a solvent-free conditions catalyzed by 1-methyl-2-oxopyrrolidinium perchlorate ionic liquid was studied. The сondensation of aromatic aldehydes, urea (thiourea), and acetoacetic ester yielded substituted 5-ethoxycarb
- Badalova,Abbasov,Valiyev,Alieva,Talybov
-
p. 2739 - 2743
(2017/12/26)
-
- 1,3,5-Tris(2-hydroxyethyl)isocyanurate functionalized graphene oxide: A novel and efficient nanocatalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2(1: H)-ones
-
In this research, the preparation, characterization and catalytic application of a novel 1,3,5-tris(2-hydroxyethyl)isocyanurate functionalized graphene oxide (GO-THEIC) nanomaterial are described. The GO/THEIC nanomaterial was characterized by Fourier tra
- Dekamin, Mohammad G.,Mehdipoor, Fatemeh,Yaghoubi, Amene
-
p. 6893 - 6901
(2017/07/17)
-
- (C5H6N4O)(C5H5N4O)3(C5H4N4O)[Bi2Cl11]Cl2 as a simple and efficient catalyst in Biginelli reaction
-
A highly efficient and facile procedure for the one-pot three-component synthesis of 3,4-dihydropyrimidin-2-(1H)ones/thiones from the one-pot condensation of aldehyde, β-dicarbonyl compound and urea/thiourea was developed. The methodology is applicable to
- Zhang, Xiang,Gu, Xiaoyu,Gao, Yuhua,Nie, Shipeng,Lu, Hongfei
-
-
- A reactant promoted solvent free synthesis of 3,4-dihydropyrimidin-2(1H)-thione analogues using ammonium thiocyanate
-
This is the first-time ammonium thiocyanate (NH4SCN) has been used as a self-promoting reactant for the synthesis of 3,4-dihydropyrimidin-2(1H)-thiones. This report describes a greener, efficient and economic protocol for one pot three-component synthesis of Biginelli compounds using various aldehydes, β-ketoesters and ammonium thiocyanate. Ammonium thiocyanate being a weak acid, accelerate the rate of reaction to obtain Biginelli compounds in solvent-free condition at 110?°C. The key advantages of the present method are high yields, short reaction time, solvent free condition, easy workup and ability to tolerate a variety of functional groups. Ammonium thiocyanate is readily available, cheaper, safer and industrial acceptable material which gives economical as well as ecological rewards to the present method.
- Khatri, Chetan K.,Potadar, Santoshkumar M.,Chaturbhuj, Ganesh U.
-
supporting information
p. 1778 - 1780
(2017/04/13)
-
- Aqua-mediated one-pot synthesis of Biginelli dihydropyrimidinone/thiones (DHPMs), Hantzsch dihydropyridines (DHPs), and polysubstituted pyridines sonocatalyzed by metal-supported nanocatalysts
-
In this work, catalyst composition-activity relationship of supported catalysts in Biginelli and Hantzsch reactions was investigated under mild conditions. Biginelli dihydropyrimidinone/thiones were prepared over Fe-Cu/ZSM-5 as an efficient, convenient, and environmentally benign catalyst under ultrasonic irradiation in aqueous media in very good yields. The Fe-Cu/ZSM-5-catalyzed synthesis of 1,4-dihydropyridines and their aromatization to polysubstituted pyridines and also a new one-pot, two-step, and sequential protocol for the synthesis of pyridine derivatives, employing an aldehyde, ethyl acetoacetate, and ammonium acetate under the same green experimental conditions were illustrated. Three-component condensation in the presence of supported reagent with operational simplicity, inexpensive reagents, short reaction time, high yield of products, and use of non-toxic reagents makes this synthetic protocol an attractive one.
- Safa, Kazem D.,Esmaili, Maryam,Allahvirdinesbat, Maryam
-
p. 267 - 277
(2016/01/09)
-
- Nano isopolyoxomolybdate catalyzed Biginelli reaction for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 3,4-dihydropyrimidin-2(1H)-thiones under solvent-free conditions
-
The Biginelli reaction of β-ketoesters with aryl aldehyde and urea or thiourea in the presence of a Keplerate type giant nanoporous isopolyoxomolybdate, (NH4)42[Mo72 VIMo60 VO372
- Nakhaei,Davoodnia,Yadegarian
-
p. 2870 - 2876
(2017/03/22)
-
- A unique opportunity for the utilization of glass wastes as a resource for catalytic applications: toward a cleaner environment
-
Although glass recycling has been conducted since 1970s, and even though recycled glass waste has been used in the construction of various alternative products, the utilization of glass waste for catalytic applications has not been fully considered until
- Zolfagharinia, Somayeh,Koukabi, Nadiya,Kolvari, Eskandar
-
p. 113844 - 113858
(2016/12/24)
-
- New Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Benzotriazolium-Based Ionic Liquids under Solvent-Free Conditions
-
An efficient synthesis of novel 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) and their derivatives, using Br?nsted acidic ionic liquid [C2 O2 BBTA][TFA] as a catalyst, from the condensation of aryl aldehyde, β-ketoester and urea was described. Reactions procee
- Liu, Zhiqing,Ma, Rong,Cao, Dawei,Liu, Chenjiang
-
-
- MoO2Cl2 catalyzed efficient synthesis of functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones and polyhydroquinolines: recyclability, fluorescence and biological studies
-
A simple, facile and efficient synthesis of functionalized dihydropyrimidinones and polyhydroquinolines using molybdenum(vi) dichloride dioxide (MoO2Cl2) has been developed. The present protocol demonstrates the exceptional tolerance
- Guggilapu, Sravanthi Devi,Prajapti, Santosh Kumar,Nagarsenkar, Atulya,Lalita, Guntuku,Naidu Vegi, Ganga Modi,Babu, Bathini Nagendra
-
p. 838 - 843
(2016/01/12)
-
- 1,3-Disulfonic acid benzimidazolium chloride as an efficient and recyclable ionic liquid catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones
-
1,3-Disulfonic acid benzimidazolium chloride ionic liquid ([Dsbim]Cl) was prepared, characterized and applied as an efficient, homogeneous and recyclable catalyst for the synthesis of 3,4-dihydropyrimidine-2-(1H)-ones/thiones through the one-pot three-com
- Abbasi, Mohsen
-
p. 3303 - 3314
(2016/04/05)
-
- Cu-EDTA-modified APTMS-Fe3O4@SiO2 core-shell nanocatalyst: A novel magnetic recoverable catalyst for the Biginelli reaction
-
A novel copper-ethylenediamine tetracarboxylate modified core-shell magnetic catalyst is introduced. The prepared catalyst was fully characterized by various spectroscopic analyses such as XRD, SEM, FT-IR, EDX, ICP, and CHNOS. After characterization, its
- Sheykhan, Mehdi,Yahyazadeh, Asieh,Rahemizadeh, Zahra
-
p. 34553 - 34563
(2016/05/09)
-
- Dihydropyrimidine based hydrazine dihydrochloride derivatives as potent urease inhibitors
-
Four series of heterocyclic compounds 4-dihydropyrimidine-2-thiones 7-12 (series A), N,S-dimethyl-dihydropyrimidines 13-18 (series B), hydrazine derivatives of dihydropyrimidine 19-24 (series C), and tetrazolo dihydropyrimidine derivatives 25-30 (series D
- Khan, Ajmal,Hashim, Jamshed,Arshad, Nuzhat,Khan, Ijaz,Siddiqui, Naureen,Wadood, Abdul,Ali, Muzaffar,Arshad, Fiza,Khan, Khalid Mohammed,Choudhary, M. Iqbal
-
-
- Preparation of iron-containing schiff base and ionic liquid based bifunctional periodic mesoporous organosilica and its application in the synthesis of 3,4-dihydropyrimidinones
-
A novel iron-containing Schiff base and ionic liquid based bifunctional periodic mesoporous organosilica (Fe@SBIL-BPMO) was prepared, characterized, and its catalytic application was developed. The SBIL-BPMO was first prepared by the grafting of 3-aminopr
- Elhamifar, Dawood,Nazari, Elham
-
p. 820 - 826
(2015/05/13)
-
- Natural organic acids promoted synthesis of 3, 4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions
-
Naturally occurring organic acids are reported to be highly efficient promoters for the Biginelli reaction under thermal and microwave irradiation using solvent free conditions. Among the various organic acids used, malic acid was found to be the most eff
- Thorat, Nitin M.,Thopate, Shankar R.
-
p. 210 - 216
(2015/06/23)
-
- Efficient and Green Microwave-Assisted Multicomponent Biginelli Reaction for the Synthesis of Dihydropyrimidinones Catalyzed by Heteropolyanion-Based Ionic Liquids under Solvent-Free Conditions
-
An efficient and green route for the synthesis of dihydropyrimidinones via microwave-assisted Biginelli reaction catalyzed by 3 mol% of heteropolyanion-based ionic liquids under solvent-free conditions has been reported. The practical reaction was found t
- Fu, Renzhong,Yang, Yang,Lai, Wenchen,Ma, Yongfeng,Chen, Zhikai,Zhou, Jian,Chai, Wen,Wang, Quan,Yuan, Rongxin
-
supporting information
p. 477 - 487
(2015/10/29)
-
- β-Cyclodextrin-propyl sulfonic acid: A new and eco-friendly catalyst for one-pot multi-component synthesis of 3,4-dihydropyrimidones via Biginelli reaction
-
β-Cyclodextrin-propyl sulfonic acid (β-CD-PSA) is reported as a new and eco-friendly catalyst for the synthesis of 3,4-dihydropyrimidinones from one-pot multi-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds and urea or thiourea under so
- Gong, Kai,Wang, Hualan,Wang, Shuxin,Ren, Xiaoxue
-
p. 4830 - 4834
(2015/07/27)
-
- Immobilization of phosphomolybdic acid nanoparticles on imidazole functionalized Fe3O4@SiO2: A novel and reusable nanocatalyst for one-pot synthesis of Biginelli-type 3,4-dihydro-pyrimidine-2-(1H)-ones/thiones under solven
-
This article introduces Fe3O4@SiO2-imid-H3PMo12O40 nanoparticles as heterogenic catalyst for the synthesis of 3,4-dihydropyrimidinones under solvent-free condition. This reaction proceeds t
- Javidi, Jaber,Esmaeilpour, Mohsen,Dodeji, Fatemeh Nowroozi
-
p. 308 - 315
(2015/02/03)
-
- Ammonium acetate promoted rapid and efficient synthesis of γ-Benzopyranones and 3,4-dihydropyrimidin-2(1H)-ones/thiones under solventfree conditions: A parallel scrutiny of microwave irradiation versus conventional heating
-
Simple and highly efficient approach for the synthesis of γ-Benzopyranones and 3,4-Dihydropyrimidin-2(1H)-ones/thiones using ammonium acetate as a promoter under thermal as well as microwave irradiation using solvent-free conditions has been demonstrated.
- Thorat, Nitin M.,Dengale, Rohit A.,Thopate, Shankar R.,Rohokale, Sandeep V.
-
p. 574 - 583
(2015/10/05)
-
- Keggin type phosphotungstic acid encapsulated chromium (III) terephthalate metal organic framework as active catalyst for Biginelli condensation
-
Keggin-type phosphotungstic acid (H3PW12O40, PTA) encapsulated in the mesocages of chromium-based terephthalate metal-organic framework (MIL-101) was established to be an active heterogeneous catalyst for three component B
- Saikia, Mrinal,Bhuyan, Diganta,Saikia, Lakshi
-
p. 501 - 506
(2015/10/28)
-
- Synthesis of 1-alkyl triazolium triflate room temperature ionic liquids and their catalytic studies in multi-component Biginelli reaction
-
Synthesis of three Brnsted acid-based ionic liquids, namely, 1-ethyl-1,2,4-triazolium triflate (1a), 1-propyl-1,2,4-triazolium triflate (1b) and 1-butyl-1,2,4-triazolium triflate (1c), is described. These ionic liquids have been employed as catalysts for
- Nagarajan, Sankaranarayanan,Shaikh, Tanveer M.,Kandasamy, Elango
-
p. 1539 - 1545
(2015/12/01)
-
- Benzyltriphenylphosphonium chloride: An efficient catalyst for one-pot synthesis of dihydropyrimidinones/thiones under solvent-free conditions
-
An efficient and one-pot method for the preparation of 3,4-dihydropyrimidin-2(1H)-ones/thiones is described. Benzyltriphenylphosphonium chloride (BTPPC) under solvent free conditions catalyzes this multi-component condensation reaction to afford the corre
- Alikarami, Mohammad,Moradi, Ronak
-
p. 560 - 565
(2015/10/05)
-
- Efficient, stable, and reusable Lewis acid-surfactant-combined catalyst: One-pot Biginelli and solvent-free esterification reactions
-
Cerium(III) trislaurylsulfonate (Ce(LS)3), a Lewis acid and surfactant combined catalyst, was prepared and characterized by SEM, SEM-EDX, XRD, NMR, FT-IR, TG, and elemental analysis. Ce(LS)3 was found to be stable and efficient to catalyze one-pot Biginelli and solvent-free esterification reactions. Furthermore, Ce(LS)3 is easy to recycle after reaction by pouring into cold water and filtration. Present work will shed deep insight into the understanding of the catalytic nature of LASCs, and extend its application in important organic transformations.
- Qiu, Yunfeng,Sun, Hongnan,Ma, Zhuo,Xia, Wujiong
-
-
- Carbon nanotubes supported by titanium dioxide nanoparticles as recyclable and green catalyst for mild synthesis of dihydropyrimidinones/thiones
-
The catalytic activity of titanium dioxide supported on carbon nanotubes has been investigated in a one-pot three components condensation reaction (Biginelli reaction). The TiO2-CNT nanocomposites as catalyst are highly stable and completely he
- Safari, Javad,Gandomi-Ravandi, Soheila
-
p. 241 - 247
(2014/05/06)
-
- Bio-based solvent mediated synthesis of dihydropyrimidinthiones via biginelli reaction
-
(Equation present) The three-component Biginelli reaction using aldehyde, thiourea, and 1,3-dicarbonyl compounds was performed smoothly in ethyl lactate (EL) with the catalysis of trimethylsilyl chloride (TMSCl). A class of 3,4-dihydropyrimidinthiones (DH
- Xu, Zhen,Jiang, Yangyang,Zou, Shuang,Liu, Yunyun
-
p. 791 - 795
(2014/07/08)
-
- Titanium dioxide supported on MWCNTs as an eco-friendly catalyst in the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones accelerated under microwave irradiation
-
Some transition metal oxides supported on MWCNTs were prepared as novel heterogeneous catalysts using the facile processes. Then, the catalytic behaviour of transition metal oxide-MWCNT nanocomposites was investigated in the Biginelli one-pot cyclocondens
- Safari, Javad,Gandomi-Ravandi, Soheila
-
p. 3514 - 3521
(2014/08/05)
-