The present disclosure relates generally to compounds and methods for inhibiting the enzymatic activity of lysine demethylase 4 (KDM4) and treating cancer. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibiting lysine demethylase 4. Furthermore, the subject compounds and compositions are useful for the treatment of breast cancer and the like.
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Paragraph 00143; 00144
(2018/10/25)
Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models
Histone lysine demethylases (KDMs) play a vital role in the regulation of chromatin-related processes. Herein, we describe our discovery of a series of potent KDM4 inhibitors that are both cell permeable and antiproliferative in cancer models. The modulat
Chen, Young K.,Bonaldi, Tiziana,Cuomo, Alessandro,Del Rosario, Joselyn R.,Hosfield, David J.,Kanouni, Toufike,Kao, Shih-Chu,Lai, Chon,Lobo, Neethan A.,Matuszkiewicz, Jennifer,McGeehan, Andrew,O'Connell, Shawn M.,Shi, Lihong,Stafford, Jeffrey A.,Stansfield, Ryan K.,Veal, James M.,Weiss, Michael S.,Yuen, Natalie Y.,Wallace, Michael B.
supporting information
p. 869 - 874
(2017/08/16)
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