- New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies
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New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific cytotoxicity against macrophages
- Rodriguez, Jorge,Aran, Vicente J.,Boiani, Lucia,Olea-Azar, Claudio,Lavaggi, Maria Laura,Gonzalez, Mercedes,Cerecetto, Hugo,Maya, Juan Diego,Carrasco-Pozo, Catalina,Cosoy, Hernan Speisky
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scheme or table
p. 8186 - 8196
(2010/03/25)
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- BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
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The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
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Page/Page column 128-129
(2008/12/07)
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