- Enantioselective analysis of an asymmetric reaction using a chiral fluorosensor
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(Chemical Equation Presented) An axially chiral 1,8-dipyridylnaphthalene N,N′-dioxide has been employed in enantioselective fluorescence analysis of the enzymatic kinetic resolution of trans-1,2-diaminocyclohexane. The procedure eliminates cumbersome purification and derivatization steps required by traditional methods. The results demonstrate the potential of fluorescence spectroscopy using suitable chiral chemosensors for real-time analysis of the enantiomeric composition of chiral compounds and for high-throughput screening of asymmetric reactions.
- Tumambac, Gilbert E.,Wolf, Christian
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- Sequential biocatalytic resolution of (±)-trans-cyclohexane-1,2-diamine. Chemoenzymatic synthesis of an optically active polyamine
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Candida antarctica lipase-catalysed double monoaminolysis of dimethyl malonate by (±)-trans-cyclohexane-1,2-diamine allows the sequential resolution of the latter compound, affording an enantiopure bis(amidoester), (R,R)-3, which is subsequently transformed into an optically active polyamine, (R,R)-9.
- Alfonso, Ignacio,Astorga, Covadonga,Rebolledo, Francisca,Gotor, Vicente
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p. 2471 - 2472
(2007/10/03)
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