Synthesis and Reactions of 1-(2-Oxopropyl)pyridazin-6-ones
Oxopropylation of 4,5-dihalopyridazin-6-ones with chloroacetone afforded the corresponding 1-(2-oxopropyl) derivatives. Reaction of title compound with nucleophiles such as amines, alkoxides were investigated. In addition, selective reduction of 3-nitro-1-(2-oxopropyl)pyridazin-6-ones with iron/ammonium chloride in two phase solutions or zinc in acetic acid gave the corresponding 3-amino or 3-hydroxyimino derivatives.
Concurrent Alkylation-Methoxylation of 4,5-Dihalopyridazin-6-ones and Synthesis of 5-Halo-4-hydroxypyridazin-6-ones
1-Alkyl-5-halo-4-methoxypyridazin-6-ones were synthesized from 1-alkyl-4,5-dihalopyridazin-6-ones by the concurrent alkylation-methoxylation. 1-Alkyl-5-halo-4-hydroxypyridazin-6-ones were also prepared.
Cho, Su-Dong,Choi, Woo-Yong,Yoon, Yong-Jin
p. 1579 - 1582
(2007/10/03)
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