Elemental fluorine. Part 21. (1) direct fluorination of benzaldehyde derivatives
Direct fluorination of a range of benzaldehyde derivatives gives mixtures of fluorobenzaldehyde and benzoyl fluoride products in ratios that depend upon the nature of the ring substituent Electron-withdrawing substituents give predominantly benzoyl fluoride derivatives, whereas electron-donating substituents lead to fluoroarene systems. Separation of ring-fluorinated products can be easily accomplished by esterification of the benzoyl fluoride side products. Scale-up of these processes to provide significant quantities of appropriate fluorobenzaldehyde systems has also been achieved using continuous flow techniques.
Chambers, Richard D.,Sandford, Graham,Trmcic, Jelena,Okazoe, Takashi
p. 339 - 344
(2013/01/03)
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