Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2- imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity.
Shankaran,Donnelly, Karla L.,Shah, Shrenik K.,Guthikonda, Ravindra N.,MacCoss, Malcolm,Humes, John L.,Pacholok, Stephen G.,Grant, Stephan K.,Kelly,Wong
p. 4539 - 4544
(2007/10/03)
STEREOSPECIFIC SYNTHESIS OF THIAZOLIDINE-2-THIONES
The synthesis of thiazolidine-2-thiones from vic-iodoalkanecarbamates, stereospecifically obtained from cis and trans-butene, is reported.Reaction of the iodo-derivatives with potassium ethylxanthate and sodium hydroxide, allowed the stereospecific format
Brunet, Ernesto,Carreno, M. Carmen,Ruano, Jose Luis Garcia
p. 1181 - 1195
(2007/10/02)
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