- PIPERIDINE AND PYROOLIDINE COMPOUNDS
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The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 12
(2011/04/13)
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- 1,2-DIAMIDO-ETHYLENE DERIVATIVES AS OREXIN ANTAGONISTS
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The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) wherein R1, R2, R3, and A are as described in the description and their use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 24
(2011/11/06)
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- 3-HETEROARYL (AMINO OR AMIDO)-1-(BIPHENYL OR PHENYLTHIAZOLYL) CARBONYLPIPERIDINE DERIVATIVES AS OREXIN RECEPTOR INHIBITORS
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The invention relates to piperidine compounds of formula (I) wherein X-R1 represents —N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or
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Page/Page column 10
(2010/04/23)
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- THIAZOLIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to novel thiazolidine derivatives of the formula (I) wherein A and R1 are as described in the description and their use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 21
(2010/05/13)
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- PYRROLIDINES AND PIPERIDINES AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to compounds of formula (I) wherein Y, A, N and R1 are as described in the description, to salts, especially pharmaceutically acceptable salts, of such compounds and to the use of such compounds as medicaments, especially
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Page/Page column 11
(2010/08/08)
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- AZETIDINE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
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The invention relates to novel azetidine compounds of formula (I), wherein R1, R2, and X are as described in the description and their use as orexin receptor antagonists.
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Page/Page column 23
(2010/09/07)
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- TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES
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The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.
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Page/Page column 50
(2009/03/07)
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- 1,2-DIAMIDO-ETHYLENE DERIVATIVES
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The invention relates to 1,2-diamido-ethylene derivatives of the formula (I) NHNR 3 OAOR 1 R 2 (I) wherein R1, R 2, R 3, and A are as described in the description and their use as medicaments, especially as orexin receptor
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Page/Page column 54
(2009/04/25)
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- 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES
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The invention relates to novel 2-aza-bicyclo[2.2.1]heptane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as m
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Page/Page column 40-41
(2009/10/18)
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- PIPERIDINE AND PYRROLIDINE COMPOUNDS
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The invention relates to piperidine and pyrrolidine compounds of formula (I) wherein A, B, n and X are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 25
(2009/12/05)
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- PIPERIDINE COMPOUNDS
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The invention relates to piperidine compounds of formula (I) wherein X-R1 represents -N(H)-pyrimidinyl, wherein said pyrimidinyl is unsubstituted or mono-substituted wherein the substituent is selected from (C1-4)alkyl or halogen, or
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Page/Page column 21
(2008/12/06)
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- 2-CYCLOPROPYL-THIAZOLE DERIVATIVES
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The invention relates to selected 2-cyclopropyl-thiazole derivatives of the formula (I) wherein B, Y and R1 are as described in the description; to salts and especially pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
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Page/Page column 44
(2009/01/20)
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- Substituted benzaldehydes in the darzens condensation with alkyl dihaloacetates
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The Darzens reaction of dihaloacetic acid esters with aromatic aldehydes produces either arylhaloglycidic or arylhalopyruvic esters depending on the nature of the substituent in the aromatic ring. Alkyl p- methoxyphenylchloropyruvates undergo spontaneous intermolecular cyclocondensation to form pyranone or furanone derivatives depending on the character of the alkyl fragment.
- Mamedov,Berdnikov,Tsuboi,Hamamoto,Komiyama,Gorbunova,Gubaidullin,Litvinov
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p. 1455 - 1463
(2007/10/03)
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- Synthesis of β-chloro-α-cyano-α-hydroxyesters
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Regioselective ring opening of 3-aryl-2-cyano 2-(methoxy and ethoxycarbonyl) oxiranes 1 with chlorhydric acids gave halohydrins 3 with OH, CN and CO2Me or CO2Et on the same carbon atom. - Keywords: oxirane; β-chloro-α-cyano-α-hydroxyester; ketoester; regi
- Ouladyakhlef, Abdesalam,Boukhris, Said,Souizi, Abdelaziz,Robert, Albert
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p. 111 - 114
(2007/10/03)
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