The present invention provides a short, safe, inexpensive, commercially scalable process for preparing a phosphorylated amino acid of Formula I, which can be performed in one pot without isolating any synthetic intermediates.
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Page/Page column 70-71; 75; 78
(2013/03/26)
PROCESS FOR PREPARING PHOSPHORYLATED AMINO ACIDS
The present invention provides a short, safe, inexpensive, commercially scalable process for preparing a phosphorylated amino acid of Formula I, which can be performed in one pot without isolating any synthetic intermediates.
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Page/Page column 82; 85
(2013/03/26)
A general preparation of protected phosphoamino acids
Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
Petrillo, Daniel E.,Mowrey, Dale R.,Allwein, Shawn P.,Bakale, Roger P.
supporting information; experimental part
p. 1206 - 1209
(2012/05/04)
Preparation and Use of Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine in Continuous Flow Solid Phase Peptide Synthesis
Nα-Fluorenylmethoxycarbonyl-O-dibenzylphosphono-L-tyrosine is a useful derivative for the solid phase synthesis of O-phosphotyrosine peptides.
Kitas, Eric A.,Wade, John D.,Johns, R. B.,Perich, John W.,Tregear, Geoffrey W.
p. 338 - 339
(2007/10/02)
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