A remarkable divergent fluorescence response to epimeric monosaccharides by an isoquinoline-derived diboronate
Herein we report a new boronic acid fluorescent sensor based on 4-isoquinolineboronic acid that has a fluorescent divergent response biologically relevant monosaccharides, glucose and galactose. By analyzing the interactions of this sensor with several alternate sugar forms we have been able to determine how the boronic acid selects diols for binding and how such a molecule could have a positive and negative fluorescent response to two very similar hexoses.
Garget, Taylor A.,Houston, Todd A.,Kiefel, Milton J.
supporting information
(2022/03/09)
Pyrrolopyrimidines and Pyrrolopyridines
Compounds of formula I in free or salt or solvate form, wherein X, T1, T3 and T4 have the meanings as indicated in the specification, are useful for treating diseases mediated by the ALK-5 and/or ALK-4 receptor. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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Page/Page column 50
(2009/07/25)
Azabicyclic inhibitors of serotonin reuptake
This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes of furmula (I) which are useful for the inhibition of serotonin reuptake in mammals. whereA-B is -C=CH- or -CH-CH2/s
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(2008/06/13)
Inhibition of serotonin reuptake
This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes which are useful for the inhibition of serotonin reuptake in mammals.
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(2008/06/13)
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