Practical resolution of 3-phenyl-2H-azirine-2-methanol at very low temperature by using lipase immobilized on porous ceramic and optimized acylating agent
A synthetically useful primary alcohol, 3-phenyl-2H-azirine-2-methanol, was resolved efficiently by a reaction at -40 °C with a lipase immobilized on the porous ceramic (Toyonite) and vinyl butanoate in ether (E value of 130 and TTN/h value of 7800).