- GPR52 MODULATORS AND METHODS OF USE
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The present disclosure relates to compounds of Formula (I) that modulate the activity of G-protein coupled receptor 52 (GPR52), pharmaceutically acceptable salts of compounds of Formula (I), and pharmaceutical compositions thereof. Compounds, pharmaceutic
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Page/Page column 56; 58; 95
(2021/10/30)
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- Anchoring a molecular iron catalyst to solar-responsive WO3 improves the rate and selectivity of photoelectrochemical water oxidation
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Molecular catalysts help overcome the kinetic limitations of water oxidation and generally result in faster rates for water oxidation than do heterogeneous catalysts. However, molecular catalysts typically function in the dark and therefore require sacrificial oxidants such as Ce4+ or S2O82- to provide the driving force for the reaction. In this Communication, covalently anchoring a phosphonate-derivatized complex, Fe(tebppmcn)Cl2 (1), to WO3 removes the need for a sacrificial oxidant and increases the rate of photoelectrochemical water oxidation on WO3 by 60%. The dual-action catalyst, 1-WO3, also gives rise to increased selectivity for water oxidation in pH 3 Na 2SO4 (56% on bare WO3, 79% on 1-WO 3). This approach provides promising alternative routes for solar water oxidation.
- Klepser, Benjamin M.,Bartlett, Bart M.
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supporting information
p. 1694 - 1697
(2014/03/21)
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- TRIAZOLOPYRAZINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES
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Novel [1.2.4]triazolo[1,5-a]pyrazine compounds are disclosed that have a formula represented by the following (formula I). The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
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Page/Page column 88-89
(2008/06/13)
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- Modification of the pyridine moiety of non-peptidyl indole GnRH receptor antagonists.
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The synthesis of a number of indole GnRH antagonists is described. Oxidation of the pyridine ring nitrogen, combined with alkylation at the two position, led to a compound with an excellent in vitro activity profile as well as oral bioavailability in both rats and dogs.
- Simeone, Joseph P,Bugianesi, Robert L,Ponpipom, Mitree M,Yang, Yi Tien,Lo, Jane-Ling,Yudkovitz, Joel B,Cui, Jisong,Mount, George R,Ren, Rena Ning,Creighton, Mellissa,Mao, An-Hua,Vincent, Stella H,Cheng, Kang,Goulet, Mark T
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p. 3329 - 3332
(2007/10/03)
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- Triazolopyridines. 18.1 nucleophilic substitution reactions on triazolopyridines; a new route to 2,2'-Bipyridines
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The synthesis of some 5-, 6-, and 7-halogenotriazolopyridines is described and their reactions with nucleophiles. The formation or 7,7'-bitriazolopyridines provides a new synthesis of 2,2'-bipyridines.
- Jones, Gurnos,Pitman, Mark A.,Lunt, Edward,Lythgoe, David J.,Abarca, Belen,Ballesteros, Rafael,Elmasnaouy, Mostafa
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p. 8257 - 8268
(2007/10/03)
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