- Phase transfer catalyzed syntheses of 4-carboxylphenoxyacetic acid derivatives
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A series of new aryl 4-carboaryloxyphenoxyacetates (3a-e) and 4- carboanilinophenoxyacetanilides (3f-s) are synthesized by the reactions of 4- chloroformylphenoxyacetyl chloride with substituted phenols or aromatic amines via liquid-liquid phase transfer catalysis using PEG-400 as the catalyst.
- Wang, Xicun,Li, Zheng,Da, Yuxia,Chen, Jichou,Wei, Taibao
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- Synthesis, crystal structure, and physical properties of a barium(II) p-(Carboxyl-methyloxy)-benzenecarboxylic acid complex
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A coordination polymer [Ba(pcmb)(H2O)2.5] (1) was obtained by self-assembly of the corresponding metal carbonate with a flexible ligand, p-(carboxyl-methyloxy)-benzenecarboxylic acid (H2pcmb), and its structure was determined by single-crystal X-ray diffraction studies. The result revealed that complex 1 has a three-dimensional structure, in which the barium(II) atom takes a distorted eight-coordinate bicapped anti-prism arrangement. The pcmb2- anion acts as a μ4-bridge ligand, in which carboxylate groups adopt monodentate and μ3- ν2:ν1-bridging two different coordination models to generate a three-dimensional network structure. The luminescence property and thermal stability of 1 were investigated. Copyright
- Wang, Xiao-Feng,Yu, Li,Wei, Hao,Wu, Gang
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- Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols
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Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.
- Pawe?czyk, Anna,Sowa-Kasprzak, Katarzyna,Olender, Dorota,Zaprutko, Lucjusz
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- PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
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Provided herein are relates to derivatives of podophyllotoxin, compositions thereof, and using them for treating various types of cancer in a subject and/or delaying or regressing various types of tumor growths in a subject.
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Paragraph 0103-0104
(2017/05/17)
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- PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
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Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
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Paragraph 0112; 0113; 0114
(2017/05/15)
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- Copper(II)-catalyzed hydroxylation of aryl halides using glycolic acid as a ligand
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Copper(II)-catalyzed hydroxylation of aryl halides has been developed to afford functionalized phenols. The protocol utilizes the reagent combination of Cu(OH)2, glycolic acid, and NaOH in aqueous DMSO, all of which are cheap, readily available, and easily removable after the reaction. A broad range of aryl iodides and activated aryl bromides were transformed into the corresponding phenols in excellent yields. Moreover, it has been shown that C-O(alkyl)-coupled product, instead of phenol, can be predominantly formed under similar reaction conditions.
- Xiao, Yan,Xu, Yongnan,Cheon, Hwan-Sung,Chae, Junghyun
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p. 5804 - 5809
(2013/07/25)
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- FUNCTIONALIZED PHENOLIC COMPOUNDS AND POLYMERS THEREFROM
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The present invention relates to compounds of formula I, which are functionalized phenolic compounds, and polymers formed from the same. Ar—[O—(X)p—R′]q??I Polymers formed from the functionalized phenolics are expected to have controllable degradation profiles, enabling them to release an active component over a desired time range. The polymers are also expected to be useful in a variety of medical applications.
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Page/Page column 30
(2009/07/17)
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- Synthetic cation transporters incorporating crown ethers and calixarenes as headgroups and central relays: A comparison of sodium and chloride selectivity
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An earlier study showed that a calix[4]arene could function as a central relay unit to form an ion conductance pathway through a phospholipid bilayer membrane. The present study expands the range of compounds from calix[4]arene to calix[6]arene and incorporates them either as central units or as headgroups, substituting one or more diaza-18-crown-6 residues in functioning hydraphiles. Ion release was assayed by detecting either Na+ or Cl- release from phospholipid vesicles. The ion transport activity for calix[4]arenes in either position is modest, but is almost non-existent when calix[6] residues were incorporated either as head groups or central relay units. The poor activity of the calix[6]arenes may result from an inability to penetrate to the midplane of the bilayer or pass entirely through it to form a conductance pathway. The transmembrane flip-flop may result from high polarity or steric bulk, or both. A hydraphile incorporating a single -NHCOC6H4OCH2CONH- as a central relay proved to be an excellent Na+ conductor, but less selective for Cl -. The fact that this new hydraphile molecule shows selectivity for Na+ over Cl- transport and possesses two secondary amide residues in the central relay suggests a means to control ion selectivity in synthetic ion transporters. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
- Carlos Iglesias-Sanchez, Jose,Wang, Wei,Ferdani, Riccardo,Prados, Pilar,De Mendoza, Javier,Gokel, George W.
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p. 878 - 890
(2008/09/21)
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