Continuous Flow Organocatalytic Chlorination of Alkenes
A regioselective anti-dichlorination and allylic chlorination of isolated double bonds is described. Such chlorination reactions benefit from a combination of methyl phenyl sulfoxide and TMSCl. The method has been appropriately adjusted to fit the continuous flow technology requirements, aiming to a broader industrial implementation for the synthesis of pharmaceutically important compounds. Towards the same direction, a catalytic protocol has been developed, using sub-stoichiometric amount of sulfoxide and environmentally friendly H2O2 as the stoichiometric oxidant, with comparable efficacy.
Gallos, John K.,Iordanidis, Nicolaos S.,Koftis, Theocharis V.,Stathakis, Christos I.,Zografos, Alexandros L.
supporting information
p. 5058 - 5062
(2021/09/28)
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