- Ultrabright Lanthanide Nanoparticles
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Tb-doped La0.9Tb0.1F3 nanoparticles were prepared by a simple and reproducible microwave-assisted synthetic protocol in water. The nanoparticles were characterized by XRD, TEM, dynamic light scattering and inductively coup
- Goetz, Joan,Nonat, Aline,Diallo, Abdoulaye,Sy, Mohamadou,Sera, Ildan,Lecointre, Alexandre,Lefevre, Christophe,Chan, Chi Fai,Wong, Ka-Leung,Charbonnière, Lo?c J.
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Read Online
- Complexes and Ligands
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The present application provides ligands and fluorescent or luminescent complexes comprising these ligands.
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- ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS
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Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).
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Page/Page column 81
(2021/10/15)
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- Ultrabright Terbium Nanoparticles for FRET Biosensing and in Situ Imaging of Epidermal Growth Factor Receptors**
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Lanthanide-doped nanoparticles (LnNPs) have become an important class of fluorophores for advanced biosensing and bioimaging. LnNPs that are photosensitized by surface-attached antenna ligands can possess exceptional brightness. However, their functional
- Charpentier, Cyrille,Cifliku, Vjona,Goetz, Joan,Nonat, Aline,Cheignon, Clémence,Cardoso Dos Santos, Marcelina,Francés-Soriano, Laura,Wong, Ka-Leung,Charbonnière, Lo?c J.,Hildebrandt, Niko
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supporting information
p. 14602 - 14611
(2020/10/06)
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- A series of 3D metal organic frameworks based on [24-MC-6] metallacrown clusters: Structure, magnetic and luminescence properties
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Four isostructural metal organic frameworks (MOFs), namely [Co 6(HipO)6]·6H2O (1), [Mn 6(HipO)6]·6H2O (2), [Cd 6(HipO)6]·6H2O (3) and [Zn 6(HipO)6]·7H2O (4) (H3ipO = 2-hydroxyisophthalic acid), were synthesized and structurally characterized. They have a 3D (4,6)-connected framework based on [24-MC-6] metallacrown clusters ([24-MC-6]-based MOFs). The arrangements of the 24-MC-6 metallacrown SBUs show a regular change indicated by the orientation of their symmetry axes, resulting in a special dense packing mode different from other [24-MC-6]-based MOFs. The analysis of SQUID measurements reveal that compound 1 displays the dominant antiferromagnetic exchanges in 300-10 K between the adjacent Co(ii) ions and a ferromagnetic-like behavior at lower temperatures, whereas compound 2 shows an antiferromagnetic interaction between the adjacent Mn(ii) ions. Compound 1 exhibits a magnetocaloric effect (MCE) with the resulting entropy change (-ΔSm) of 15.20 J kg-1 K-1 for ΔH = 50 kG at 6 K, which is the highest value among the cobalt-based MOFs with MCE reported so far. The luminescence properties of compounds 3 and 4 were studied, both of them exhibit photoluminescence in the solid state at room temperature which can be ascribed to intraligand π→π* transitions. This journal is the Partner Organisations 2014.
- Wang, Kai,Zou, Hua-Hong,Chen, Zi-Lu,Zhang, Zhong,Sun, Wei-Yin,Liang, Fu-Pei
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supporting information
p. 12989 - 12995
(2014/08/18)
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- Light-induced water oxidation by a Ru complex containing a bio-inspired ligand
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The new Ru complex 8 containing the bio-inspired ligand 7 was successfully synthesized and characterized. Complex 8 efficiently catalyzes water oxidation using CeIV and RuIII as chemical oxidants. More importantly, this complex has a sufficiently low overpotential to utilize ruthenium polypyridyl-type complexes as photosensitizers. Water splitting: A bio-inspired ligand containing imidazole and phenol functionalities has been synthesized. The corresponding Ru complex (1) could efficiently catalyze water oxidation under visible light illumination using Ru polypyridyl-type complexes as photosensitizers. Copyright
- Kaerkaes, Markus D.,Johnston, Eric V.,Karlsson, Erik A.,Lee, Bao-Lin,Akermark, Torbjoern,Shariatgorji, Mohammadreza,Ilag, Leopold,Hansson, Oerjan,Baeckvall, Jan-E.,Akermark, Bjoern
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experimental part
p. 7953 - 7959
(2011/09/12)
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- LUMINESCENT MACROCYCLIC LANTHANIDE COMPLEXES
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The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
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Page/Page column 74
(2008/12/05)
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- A new class of intramolecularly hydrogen-bonded dendrons based on a 2-methoxyisophthalamide repeat unit
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(Chemical Equation Presented). The synthesis and conformational properties of folded dendrons based on a 2-methoxyisophthalamide (2-OMe-IPA) repeat unit are described. The hydrodynamic properties of dendrons preorganized via the syn-syn conformational pre
- Gabriel, Christopher J.,DeMatteo, Matthew P.,Paul, Noel M.,Takaya, Tomohisa,Gustafson, Terry L.,Hadad, Christopher M.,Parquette, Jon R.
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p. 9035 - 9044
(2007/10/03)
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- A minimalist approach to C-H activation by copper
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The complex [Cu2(1)2]2+ (1=1,3-bis(1-methyl-1H-benzimidazol-2-yl)benzene) undergoes slow oxidation by dioxygen in DMF solution to give the hydroxylated product [Cu 2(2-H)2]2+ (2=2,6-bis(1-methyl-1H-benzimidazol- 2-yl)phenol) characterized by an X-ray crystal-structure analysis. The oxidation occurs much faster when CuII is mixed with 1 in the presence of H2O2, with 80% hydroxylation observed within a few minutes. The mononuclear complex formed with 1-methyl-2-phenyl-1H-benzimidazole (3) shows no hydroxylation under these conditions. It is concluded that the hydroxylation requires the presence of a ligand capable of stabilizing a binuclear species, but no special coordinative activation of the copper is required.
- Kuebel-Pollak, Anita,Ruettimann, Stephane,Dunn, Nichola,Melich, Xavier,Williams, Alan F.,Bernardinelli, Gerald
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p. 841 - 853
(2007/10/03)
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- (Hetero)aryl-bicyclic heteroaryl derivatives, their preparation and their use as protease inhibitors
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The present invention provides novel compounds of the Formula (I): A-B, its prodrug forms, or pharmaceutically acceptable salts thereof, wherein A represents a saturated, unsaturated, or a partially unsaturated bicyclic heterocyclic ring structure, and B represents an aryl or a heteroaryl group. Preferred compounds of the present invention comprise a benzimidazole or indole nucleus. The compounds of this invention are inhibitors of serine proteases, Urokinase (uPA), Factor Xa (FXa), and/or Factor VIIa (FVIIa), and have utility as anti cancer agents and/or as anticoagulants for the treatment or prevention of thromboembolic disorders in mammals.
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Page/Page column 29
(2010/02/11)
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- Hydrogen-bonding-induced planar, rigid, and zigzag oligoanthranilamides. Synthesis, characterization, and self-assembly of a metallocyclophane
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Four oligoanthranilamides 1-4, which are incorporated with three, five, seven, or nine benzene units, respectively, have been synthesized and characterized. X-ray analysis, 1D and 2D 1H NMR, and IR experiments reveal that all the new oligoamide
- Zhu, Jiang,Wang, Xiao-Zhong,Chen, Ying-Qi,Jiang, Xi-Kui,Chen, Xin-Zhi,Li, Zhan-Ting
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p. 6221 - 6227
(2007/10/03)
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- METALATION REACTIONS. XIV. REGIOSPECIFIC PREPARATION OF POLYSUBSTITUTED BENZENES VIA MONO- OR DI-LITHIATION REACTIONS OF AROMATIC THIOETHERS
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The preparation of polyfunctionalized aromatic thioethers either by one-step dilithiation or by two successive one-flask monometalation reactions is described.By acting on 1 two equal or different electrophiles one on the thiomethyl group and one in the ortho-position with respect to it are introduced; by acting on 11 and on 35 the substitution involves the thiomethyl carbon atom and that in the ortho-position with respect to the alkoxy group.In the case of the homologeous isopropylthio (23) the substitution involves the two aryl carbon atoms in the ortho-position to both functions.In the case of the p-disubstituted isomers (49, 59) analogous behaviour to ortho isomers in one-step metalation reaction is observed, while the two hydrogen atoms in the ortho-positions to the methoxy group are substituted when two successive monometalations are employed.The metalation of 40 results low selective.The behaviour of 79 and 93 is analogous to 1, while 72, 88 and 96 undergo only one-step monometalation reactions.
- Cabiddu, Salvatore,Fattuoni, Claudia,Floris, Costantino,Gelli, Gioanna,Melis, Stefana,Sotgiu, Francesca
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p. 861 - 884
(2007/10/02)
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- The photocyclization of o-alkoxy phenyl ketones
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Several o-alkoxybenzophenones and o-(benzyloxy)benzophenones and -acetophenones photocyclize to 3-hydroxy-2,3-dihydrobenzofurans. Quantum yields generally are quite high, except for o-(benzyloxy)acetophenone. The o-ethoxy and o-benzyloxy ketones form two diastereomeric products, the Z isomer being highly preferred in hydrocarbon solvents, the E isomer being formed in comparable yield in methanol or with added pyridine. The reaction involves δ-hydrogen abstraction by the ketone triplets followed by cyclization of the 1,5-biradical intermediates. The biradicals have such short lifetimes that they usually cannot be detected by flash spectroscopy or trapped by thiols. Triplet state lifetimes, determined both by steady-state quenching studies and by flash kinetics, reveal that hydrogen abstraction rate constants are quite low. Arrhenius plots for triplet decay indicate activation energies of 3-5 kcal/mol and A values of 109 for the δ-hydrogen abstraction. MMX calculations and spectroscopic data all indicate that the ketones exist primarily in conformations with the carbon α to the ether oxygen twisted well away from the carbonyl. The low observed rate constants are ascribed to even lower equilibrium populations of conformers in the geometry required for reaction in the triplet state than in the ground state. 2,6-Diacylphenyl ethers show ten times the triplet reactivity of their monoacyl equivalents. In these cases, the ether function is twisted 90° such that the target C-H bond is much closer to a carbonyl. The large solvent effects on the stereochemistry of cyclization despite short biradical lifetimes suggest that bond rotations may induce intersystem crossing of the triplet biradicals. The low cyclization quantum yield from o-(benzyloxy)acetophenone and the formation of o-benzoylacetophenone as a major side product suggest that the 1,5-biradicals partially cyclize into the benzene ring to generate spiroenol intermediates. Rate constants for quenching of the triplet ketones by 2,5-dimethyl-2,4-hexadiene were measured. The kq values are ≥5 × 109 M-1 s-1 for the o-methoxy ketones but only 1-3 × 109 for the o-benzyloxy ketones. This rare steric effect on triplet energy transfer is attributed to twisting of the benzoyl chromophores caused by steric congestion.
- Wagner, Peter J.,Meador, Michael A.,Park, Bong-Ser
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p. 5199 - 5211
(2007/10/02)
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- General acid catalysis in the enolization of acetone
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We have used iodometry to study the enolization of acetone in water catalyzed by a series of general acids, comprised of hydrochloric acid, methanesulfonic acid, 24 aliphatic monocarboxylic acids, nine aromatic monocarboxylic acids, eight aiphatic dicarboxylic acids, and 20 monoanions of dicarboxylic acids.The log k-pK profile for unbuffered solutions of strong and moderately strong acids shows a maximum near pK ca. 0.The Broensted α value for a set of eight aliphatic monocarboxylic acids in which effects of bulk, charge, and polarizability are at a minimum is 0.56.Steric effects, probably augmented by polarizability effects in some cases, cause positive deviations from the Broensted line drawn with respect to these standard acids.Anionic carboxylic acids are also more reactive than would be predicted from their equilibrium acid strengths, whereas cationic acids tend to be less reactive.Using D2O as solvent has only a small effect on the rate of carboxylic acid catalysis.Using acetone-d6 gives values of kH/kD in the range of 7.0-8.0 at 25 deg C, values consistent with proton or deuteron being transferred between two bases of comparable strength, the carboxylate anion and the enol form of acetone.Key words: general acid catalysis, enolization, Broensted relation, steric effects, deuterium isotope effects.
- Shelly, Kevin P.,Venimadhavan, S.,Nagarajan, K.,Stewart, Ross
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p. 1274 - 1282
(2007/10/02)
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